BRD-K60230970_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

210 genes differentially expressed following the BRD-K60230970_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE40 basic helix-loop-helix family, member e40
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CLU clusterin
COL2A1 collagen, type II, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHCR7 7-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK4 dedicator of cytokinesis 4
DSE dermatan sulfate epimerase
EDN3 endothelin 3
EIF1 eukaryotic translation initiation factor 1
ELANE elastase, neutrophil expressed
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GRB10 growth factor receptor-bound protein 10
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KRT13 keratin 13, type I
LCN2 lipocalin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFSD10 major facilitator superfamily domain containing 10
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MPO myeloperoxidase
MSMO1 methylsterol monooxygenase 1
NAP1L1 nucleosome assembly protein 1-like 1
NFIL3 nuclear factor, interleukin 3 regulated
NOTCH1 notch 1
NPC1 Niemann-Pick disease, type C1
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
RABGGTB Rab geranylgeranyltransferase, beta subunit
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RTCA RNA 3'-terminal phosphate cyclase
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAR steroidogenic acute regulatory protein
STK38L serine/threonine kinase 38 like
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM41B transmembrane protein 41B
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UBE3C ubiquitin protein ligase E3C
UPP1 uridine phosphorylase 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALDOB aldolase B, fructose-bisphosphate
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT1
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1R complement component 1, r subcomponent
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CD9 CD9 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CENPA centromere protein A
CLIC3 chloride intracellular channel 3
COLEC12 collectin sub-family member 12
CRIP2 cysteine-rich protein 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXADR coxsackie virus and adenovirus receptor
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DEPTOR DEP domain containing MTOR-interacting protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
EHD3 EH-domain containing 3
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FBP1 fructose-1,6-bisphosphatase 1
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
FOXA1 forkhead box A1
GALE UDP-galactose-4-epimerase
GAS2L1 growth arrest-specific 2 like 1
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSTM3 glutathione S-transferase mu 3 (brain)
GTSE1 G-2 and S-phase expressed 1
HES1 hes family bHLH transcription factor 1
HMG20B high mobility group 20B
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP5 insulin-like growth factor binding protein 5
IRS1 insulin receptor substrate 1
ITGB4 integrin, beta 4
KIAA0907 KIAA0907
KIF20A kinesin family member 20A
KYNU kynureninase
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
MLPH melanophilin
MRPL57 mitochondrial ribosomal protein L57
MUC1 mucin 1, cell surface associated
NCAPD2 non-SMC condensin I complex, subunit D2
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME3 NME/NM23 nucleoside diphosphate kinase 3
PDE4B phosphodiesterase 4B, cAMP-specific
PIP prolactin-induced protein
PLBD1 phospholipase B domain containing 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRR7 proline rich 7 (synaptic)
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RSRP1 arginine/serine-rich protein 1
SCGB2A2 secretoglobin, family 2A, member 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPTSSA serine palmitoyltransferase, small subunit A
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM7SF2 transmembrane 7 superfamily member 2
TMC5 transmembrane channel-like 5
TMEM223 transmembrane protein 223
TMEM251 transmembrane protein 251
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
UBE2C ubiquitin-conjugating enzyme E2C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VNN1 vanin 1