BRD-K60230970_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

247 genes differentially expressed following the BRD-K60230970_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADGRG2 adhesion G protein-coupled receptor G2
AKAP13 A kinase (PRKA) anchor protein 13
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BPGM 2,3-bisphosphoglycerate mutase
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CAPN2 calpain 2, (m/II) large subunit
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL4A5 collagen, type IV, alpha 5
CSRP2 cysteine and glycine-rich protein 2
CTSL cathepsin L
CXCL13 chemokine (C-X-C motif) ligand 13
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GPR161 G protein-coupled receptor 161
GRB10 growth factor receptor-bound protein 10
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IGHMBP2 immunoglobulin mu binding protein 2
JAG1 jagged 1
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
LBH limb bud and heart development
LCN2 lipocalin 2
LPIN1 lipin 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP2 microfibrillar-associated protein 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MXI1 MAX interactor 1, dimerization protein
NPC1 Niemann-Pick disease, type C1
NRIP3 nuclear receptor interacting protein 3
NSDHL NAD(P) dependent steroid dehydrogenase-like
P3H2 prolyl 3-hydroxylase 2
POPDC3 popeye domain containing 3
PTHLH parathyroid hormone-like hormone
PTK2B protein tyrosine kinase 2 beta
RBMS1 RNA binding motif, single stranded interacting protein 1
RND3 Rho family GTPase 3
S100P S100 calcium binding protein P
SCPEP1 serine carboxypeptidase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SRGN serglycin
TMEM41B transmembrane protein 41B
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WFDC1 WAP four-disulfide core domain 1
WLS wntless Wnt ligand secretion mediator
WT1 Wilms tumor 1
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANXA9 annexin A9
APITD1 apoptosis-inducing, TAF9-like domain 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3ORF14 chromosome 3 open reading frame 14
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CHMP4A charged multivesicular body protein 4A
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
DPYD dihydropyrimidine dehydrogenase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
F12 coagulation factor XII (Hageman factor)
FAM216A family with sequence similarity 216, member A
FANCI Fanconi anemia, complementation group I
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
FXYD3 FXYD domain containing ion transport regulator 3
GALE UDP-galactose-4-epimerase
GATA3 GATA binding protein 3
GBAS glioblastoma amplified sequence
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTF3A general transcription factor IIIA
GTSE1 G-2 and S-phase expressed 1
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HLF hepatic leukemia factor
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ICMT isoprenylcysteine carboxyl methyltransferase
IFRD2 interferon-related developmental regulator 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KRT15 keratin 15, type I
LAGE3 L antigen family, member 3
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MLPH melanophilin
MSRA methionine sulfoxide reductase A
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NBN nibrin
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NHP2 NHP2 ribonucleoprotein
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRC1 protein regulator of cytokinesis 1
PRR7 proline rich 7 (synaptic)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RAB25 RAB25, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SEPW1 selenoprotein W, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STMN1 stathmin 1
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPD52L1 tumor protein D52-like 1
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TSPAN4 tetraspanin 4
TSPYL5 TSPY-like 5
TST thiosulfate sulfurtransferase (rhodanese)
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
WDR61 WD repeat domain 61
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein