BRD-K60219430_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K60219430_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
APLP2 amyloid beta (A4) precursor-like protein 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
FADS2 fatty acid desaturase 2
FDPS farnesyl diphosphate synthase
FZD7 frizzled class receptor 7
GCLC glutamate-cysteine ligase, catalytic subunit
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LBH limb bud and heart development
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PGD phosphogluconate dehydrogenase
PLK2 polo-like kinase 2
PSAP prosaposin
QPCT glutaminyl-peptide cyclotransferase
RBPMS RNA binding protein with multiple splicing
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SQLE squalene epoxidase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSC cathepsin C
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
GABPB1 GA binding protein transcription factor, beta subunit 1
GLDC glycine dehydrogenase (decarboxylating)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC10 homeobox C10
HOXC6 homeobox C6
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
MKI67 marker of proliferation Ki-67
MT1E metallothionein 1E
MT1F metallothionein 1F
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEPP1 selenoprotein P, plasma, 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SRGN serglycin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C