BRD-K60219430_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K60219430_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
AMIGO2 adhesion molecule with Ig-like domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BTG1 B-cell translocation gene 1, anti-proliferative
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CRABP1 cellular retinoic acid binding protein 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DHCR7 7-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELOVL6 ELOVL fatty acid elongase 6
FAM60A family with sequence similarity 60, member A
FOSL1 FOS-like antigen 1
GATA6 GATA binding protein 6
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPCAL1 hippocalcin-like 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LDLR low density lipoprotein receptor
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MCL1 myeloid cell leukemia 1
MSMO1 methylsterol monooxygenase 1
NMU neuromedin U
NPC1 Niemann-Pick disease, type C1
NR1H2 nuclear receptor subfamily 1, group H, member 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB4 phospholipase C, beta 4
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RGS4 regulator of G-protein signaling 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SNX7 sorting nexin 7
SQLE squalene epoxidase
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB3 tribbles pseudokinase 3

decreased expression

Symbol Name
BASP1 brain abundant, membrane attached signal protein 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DMD dystrophin
FGFR3 fibroblast growth factor receptor 3
GCLC glutamate-cysteine ligase, catalytic subunit
HLF hepatic leukemia factor
IL17RB interleukin 17 receptor B
ITM2A integral membrane protein 2A
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF20A kinesin family member 20A
MET MET proto-oncogene, receptor tyrosine kinase
MMP12 matrix metallopeptidase 12
MXRA5 matrix-remodelling associated 5
NR2F1 nuclear receptor subfamily 2, group F, member 1
PCDH9 protocadherin 9
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPL periplakin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RCC1 regulator of chromosome condensation 1
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
SERBP1 SERPINE1 mRNA binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TOP2A topoisomerase (DNA) II alpha 170kDa