BRD-K60067222_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K60067222_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACE2 angiotensin I converting enzyme 2
ADGRF5 adhesion G protein-coupled receptor F5
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARHGAP29 Rho GTPase activating protein 29
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG2 BCL2-associated athanogene 2
BMP4 bone morphogenetic protein 4
C4BPA complement component 4 binding protein, alpha
CD300A CD300a molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEMIP cell migration inducing protein, hyaluronan binding
CFI complement factor I
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DEFB4A defensin, beta 4A
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDNRB endothelin receptor type B
F12 coagulation factor XII (Hageman factor)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM63A family with sequence similarity 63, member A
FBLN5 fibulin 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FXYD5 FXYD domain containing ion transport regulator 5
G0S2 G0/G1 switch 2
GCHFR GTP cyclohydrolase I feedback regulator
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GPR65 G protein-coupled receptor 65
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JCHAIN joining chain of multimeric IgA and IgM
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LEF1 lymphoid enhancer-binding factor 1
LTF lactotransferrin
LXN latexin
LY86 lymphocyte antigen 86
MACF1 microtubule-actin crosslinking factor 1
MBNL2 muscleblind-like splicing regulator 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MSN moesin
MSX2 msh homeobox 2
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NMB neuromedin B
NTS neurotensin
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDZK1IP1 PDZK1 interacting protein 1
PI3 peptidase inhibitor 3, skin-derived
PLIN2 perilipin 2
PRAF2 PRA1 domain family, member 2
PRAME preferentially expressed antigen in melanoma
PRKCH protein kinase C, eta
PROCR protein C receptor, endothelial
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RGS10 regulator of G-protein signaling 10
RHOB ras homolog family member B
RHOC ras homolog family member C
RNF167 ring finger protein 167
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN2 reticulon 2
S100A7 S100 calcium binding protein A7
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK26 serine/threonine protein kinase 26
STS steroid sulfatase (microsomal), isozyme S
SYT1 synaptotagmin I
TM4SF1 transmembrane 4 L six family member 1
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
BAG1 BCL2-associated athanogene
C6ORF62 chromosome 6 open reading frame 62
CA1 carbonic anhydrase I
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD24 CD24 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL9A3 collagen, type IX, alpha 3
CRISP3 cysteine-rich secretory protein 3
CXCL13 chemokine (C-X-C motif) ligand 13
DSP desmoplakin
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EZR ezrin
FKBP5 FK506 binding protein 5
FN1 fibronectin 1
KLF6 Kruppel-like factor 6
LAMP1 lysosomal-associated membrane protein 1
MCL1 myeloid cell leukemia 1
MMP9 matrix metallopeptidase 9
PCDH9 protocadherin 9
PDGFA platelet-derived growth factor alpha polypeptide
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLEC plectin
PMP22 peripheral myelin protein 22
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RXRA retinoid X receptor, alpha
SATB1 SATB homeobox 1
SATB2 SATB homeobox 2
SCARB2 scavenger receptor class B, member 2
SDC2 syndecan 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF91 zinc finger protein 91