BRD-K60067222_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K60067222_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ANXA1 annexin A1
APOD apolipoprotein D
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A1 collagen, type I, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CTSL cathepsin L
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
EGLN3 egl-9 family hypoxia-inducible factor 3
EPAS1 endothelial PAS domain protein 1
FGFR1 fibroblast growth factor receptor 1
FN1 fibronectin 1
FOXO4 forkhead box O4
FXYD5 FXYD domain containing ion transport regulator 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS1 growth arrest-specific 1
GBP2 guanylate binding protein 2, interferon-inducible
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GNB5 guanine nucleotide binding protein (G protein), beta 5
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IL32 interleukin 32
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITM2C integral membrane protein 2C
KRT23 keratin 23, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LOXL2 lysyl oxidase-like 2
MFAP2 microfibrillar-associated protein 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTMR11 myotubularin related protein 11
MVP major vault protein
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NES nestin
PAM peptidylglycine alpha-amidating monooxygenase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PMP22 peripheral myelin protein 22
PON2 paraoxonase 2
POR P450 (cytochrome) oxidoreductase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PROM1 prominin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTN pleiotrophin
PYGL phosphorylase, glycogen, liver
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNAI2 snail family zinc finger 2
SRI sorcin
STC1 stanniocalcin 1
SYT1 synaptotagmin I
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
TUBB2B tubulin, beta 2B class IIb
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
WLS wntless Wnt ligand secretion mediator
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ATAD2 ATPase family, AAA domain containing 2
BRCA1 breast cancer 1, early onset
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNE2 cyclin E2
CD24 CD24 molecule
CDC6 cell division cycle 6
CXCL13 chemokine (C-X-C motif) ligand 13
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
ICAM3 intercellular adhesion molecule 3
IFRD2 interferon-related developmental regulator 2
JADE2 jade family PHD finger 2
KLK11 kallikrein-related peptidase 11
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NUP98 nucleoporin 98kDa
PBK PDZ binding kinase
PITX1 paired-like homeodomain 1
PPIF peptidylprolyl isomerase F
PRMT1 protein arginine methyltransferase 1
PTX3 pentraxin 3, long
RFC2 replication factor C (activator 1) 2, 40kDa
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TRIM28 tripartite motif containing 28
TSPYL5 TSPY-like 5
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1