BRD-K60038276_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K60038276_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BTG3 BTG family, member 3
C6ORF62 chromosome 6 open reading frame 62
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CCDC86 coiled-coil domain containing 86
CD40 CD40 molecule, TNF receptor superfamily member 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
FOLR1 folate receptor 1 (adult)
FZD6 frizzled class receptor 6
H2AFV H2A histone family, member V
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MT1M metallothionein 1M
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NXN nucleoredoxin
OBSL1 obscurin-like 1
ORC1 origin recognition complex, subunit 1
P3H2 prolyl 3-hydroxylase 2
PDZD2 PDZ domain containing 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PRKCI protein kinase C, iota
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RHOBTB3 Rho-related BTB domain containing 3
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC38A1 solute carrier family 38, member 1
SOSTDC1 sclerostin domain containing 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPTSSA serine palmitoyltransferase, small subunit A
SSBP2 single-stranded DNA binding protein 2
STS steroid sulfatase (microsomal), isozyme S
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
BCHE butyrylcholinesterase
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRELD2 cysteine-rich with EGF-like domains 2
FADS2 fatty acid desaturase 2
GAS1 growth arrest-specific 1
GPX4 glutathione peroxidase 4
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KIF14 kinesin family member 14
KYNU kynureninase
LIPG lipase, endothelial
MFSD12 major facilitator superfamily domain containing 12
NFIB nuclear factor I/B
NQO2 NAD(P)H dehydrogenase, quinone 2
PALLD palladin, cytoskeletal associated protein
PCDH9 protocadherin 9
PDLIM5 PDZ and LIM domain 5
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNMA1 paraneoplastic Ma antigen 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPL36 ribosomal protein L36
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORD sorbitol dehydrogenase
SPEN spen family transcriptional repressor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
SYNM synemin, intermediate filament protein
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S
UQCRH ubiquinol-cytochrome c reductase hinge protein