BRD-K59632282_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K59632282_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
AREG amphiregulin
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF1 activating transcription factor 1
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCNA1 cyclin A1
CCND2 cyclin D2
CENPE centromere protein E, 312kDa
CFI complement factor I
CHPT1 choline phosphotransferase 1
COTL1 coactosin-like F-actin binding protein 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DUSP22 dual specificity phosphatase 22
EXOSC4 exosome component 4
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
FOXO3 forkhead box O3
GPX3 glutathione peroxidase 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
ISOC1 isochorismatase domain containing 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LAMP1 lysosomal-associated membrane protein 1
LPIN2 lipin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEGF9 multiple EGF-like-domains 9
MSRA methionine sulfoxide reductase A
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NUP93 nucleoporin 93kDa
ODC1 ornithine decarboxylase 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAD23B RAD23 homolog B (S. cerevisiae)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SLC16A4 solute carrier family 16, member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
STAT1 signal transducer and activator of transcription 1, 91kDa
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TBL1X transducin (beta)-like 1X-linked
TFF1 trefoil factor 1
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM2 absent in melanoma 2
ALAS1 5'-aminolevulinate synthase 1
C10ORF10 chromosome 10 open reading frame 10
C2CD5 C2 calcium-dependent domain containing 5
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CHGB chromogranin B
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CRABP1 cellular retinoic acid binding protein 1
CSTA cystatin A (stefin A)
CXCL13 chemokine (C-X-C motif) ligand 13
DLK1 delta-like 1 homolog (Drosophila)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPT dermatopontin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FZD6 frizzled class receptor 6
GNAS GNAS complex locus
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
KRT81 keratin 81, type II
MECOM MDS1 and EVI1 complex locus
MMP2 matrix metallopeptidase 2
NRN1 neuritin 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN2 reticulon 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SNX7 sorting nexin 7
TCF4 transcription factor 4
TDO2 tryptophan 2,3-dioxygenase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TPBG trophoblast glycoprotein
TWIST1 twist family bHLH transcription factor 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1
XIST X inactive specific transcript (non-protein coding)