BRD-K59369769_tozasertib_MCF7_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K59369769_tozasertib_MCF7_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CCL19 chemokine (C-C motif) ligand 19
CCND2 cyclin D2
CGA glycoprotein hormones, alpha polypeptide
CH25H cholesterol 25-hydroxylase
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DCT dopachrome tautomerase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DSP desmoplakin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAS Fas cell surface death receptor
FCGBP Fc fragment of IgG binding protein
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FN1 fibronectin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GPNMB glycoprotein (transmembrane) nmb
GREB1 growth regulation by estrogen in breast cancer 1
GZMK granzyme K (granzyme 3; tryptase II)
HMGA2 high mobility group AT-hook 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
MICALL1 MICAL-like 1
MT1G metallothionein 1G
MT1X metallothionein 1X
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCLO piccolo presynaptic cytomatrix protein
PEG3 paternally expressed 3
PLP1 proteolipid protein 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100A7 S100 calcium binding protein A7
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STXBP1 syntaxin binding protein 1
TNC tenascin C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WASF1 WAS protein family, member 1

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ACKR3 atypical chemokine receptor 3
ADGRF5 adhesion G protein-coupled receptor F5
ADRB2 adrenoceptor beta 2, surface
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
ASPN asporin
BAX BCL2-associated X protein
BGN biglycan
BID BH3 interacting domain death agonist
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CNPY3 canopy FGF signaling regulator 3
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CRIP2 cysteine-rich protein 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R2 cytochrome b5 reductase 2
DCN decorin
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
FAP fibroblast activation protein, alpha
FKBP14 FK506 binding protein 14, 22 kDa
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPH1 heat shock 105kDa/110kDa protein 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
IPO13 importin 13
ISG15 ISG15 ubiquitin-like modifier
LCN2 lipocalin 2
LIMCH1 LIM and calponin homology domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS1 Meis homeobox 1
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
PDLIM3 PDZ and LIM domain 3
PDLIM5 PDZ and LIM domain 5
PECAM1 platelet/endothelial cell adhesion molecule 1
PLK2 polo-like kinase 2
PPIC peptidylprolyl isomerase C (cyclophilin C)
PROM1 prominin 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGS5 regulator of G-protein signaling 5
RNH1 ribonuclease/angiogenin inhibitor 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
SCAND1 SCAN domain containing 1
SLC25A46 solute carrier family 25, member 46
SLPI secretory leukocyte peptidase inhibitor
SPP1 secreted phosphoprotein 1
SRGN serglycin
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TLR4 toll-like receptor 4
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TYROBP TYRO protein tyrosine kinase binding protein
UBE3C ubiquitin protein ligase E3C
ZNF423 zinc finger protein 423
ZNF91 zinc finger protein 91