BRD-K59369769_tozasertib_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K59369769_tozasertib_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAX BCL2-associated X protein
CAV2 caveolin 2
CCL5 chemokine (C-C motif) ligand 5
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CXCL9 chemokine (C-X-C motif) ligand 9
EBI3 Epstein-Barr virus induced 3
EMP3 epithelial membrane protein 3
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLV3-19 immunoglobulin lambda variable 3-19
METTL7A methyltransferase like 7A
NEBL nebulette
PALLD palladin, cytoskeletal associated protein
PBX3 pre-B-cell leukemia homeobox 3
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFD platelet derived growth factor D
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A14 S100 calcium binding protein A14
SCGB2A2 secretoglobin, family 2A, member 2
SESN1 sestrin 1
SLIT2 slit homolog 2 (Drosophila)
STOM stomatin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIM22 tripartite motif containing 22
VAT1 vesicle amine transport 1
WDR7 WD repeat domain 7
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CACYBP calcyclin binding protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDH3 cadherin 3, type 1, P-cadherin (placental)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F3 coagulation factor III (thromboplastin, tissue factor)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HP haptoglobin
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IFI16 interferon, gamma-inducible protein 16
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
KDM5D lysine (K)-specific demethylase 5D
KLK11 kallikrein-related peptidase 11
LCN2 lipocalin 2
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
NPY neuropeptide Y
NUSAP1 nucleolar and spindle associated protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRSS2 protease, serine, 2 (trypsin 2)
RAD51AP1 RAD51 associated protein 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SST somatostatin
TRIB2 tribbles pseudokinase 2