BRD-K59317601_INK-128_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K59317601_INK-128_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAMDEC1 ADAM-like, decysin 1
AHR aryl hydrocarbon receptor
AIM2 absent in melanoma 2
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
CD9 CD9 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHIC2 cysteine-rich hydrophobic domain 2
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DUOX2 dual oxidase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHB2 EPH receptor B2
FAM63A family with sequence similarity 63, member A
FAM69A family with sequence similarity 69, member A
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX1 glutathione peroxidase 1
GRN granulin
GSN gelsolin
H1F0 H1 histone family, member 0
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IDS iduronate 2-sulfatase
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KYNU kynureninase
LDOC1 leucine zipper, down-regulated in cancer 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MTA1 metastasis associated 1
OLFM4 olfactomedin 4
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDGFD platelet derived growth factor D
PEX11A peroxisomal biogenesis factor 11 alpha
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAU plasminogen activator, urokinase
PRSS23 protease, serine, 23
PTN pleiotrophin
RAB13 RAB13, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM47 RNA binding motif protein 47
REG3A regenerating islet-derived 3 alpha
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SIK1 salt-inducible kinase 1
STAB1 stabilin 1
TBX3 T-box 3
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ANXA6 annexin A6
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
BEX1 brain expressed, X-linked 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CBR1 carbonyl reductase 1
CCND1 cyclin D1
CCNE2 cyclin E2
CDC7 cell division cycle 7
CHEK2 checkpoint kinase 2
COTL1 coactosin-like F-actin binding protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GPI glucose-6-phosphate isomerase
GRIA2 glutamate receptor, ionotropic, AMPA 2
KIAA0101 KIAA0101
LTF lactotransferrin
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCM3 minichromosome maintenance complex component 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICB MHC class I polypeptide-related sequence B
MTCH2 mitochondrial carrier 2
MYCBP MYC binding protein
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG3 paternally expressed 3
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX2 peroxiredoxin 2
PROM1 prominin 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PUF60 poly-U binding splicing factor 60KDa
RANBP1 RAN binding protein 1
RBBP7 retinoblastoma binding protein 7
RFC2 replication factor C (activator 1) 2, 40kDa
SCRG1 stimulator of chondrogenesis 1
SFN stratifin
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMC1A structural maintenance of chromosomes 1A
STAR steroidogenic acute regulatory protein
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TMEM97 transmembrane protein 97
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
VBP1 von Hippel-Lindau binding protein 1
VDAC1 voltage-dependent anion channel 1