BRD-K59317601_INK-128_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-K59317601_INK-128_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADCY1 adenylate cyclase 1 (brain)
AGR2 anterior gradient 2
AMOTL2 angiomotin like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA4 annexin A4
AREG amphiregulin
BIK BCL2-interacting killer (apoptosis-inducing)
BLNK B-cell linker
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CCDC92 coiled-coil domain containing 92
CCNG1 cyclin G1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CLDN3 claudin 3
CST1 cystatin SN
CTSK cathepsin K
CYFIP2 cytoplasmic FMR1 interacting protein 2
DARS aspartyl-tRNA synthetase
DAXX death-domain associated protein
DCLK1 doublecortin-like kinase 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DEPTOR DEP domain containing MTOR-interacting protein
DOCK9 dedicator of cytokinesis 9
DPP4 dipeptidyl-peptidase 4
DUSP4 dual specificity phosphatase 4
EAPP E2F-associated phosphoprotein
EIF4B eukaryotic translation initiation factor 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM69A family with sequence similarity 69, member A
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GAA glucosidase, alpha; acid
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GRN granulin
HBP1 HMG-box transcription factor 1
HIP1R huntingtin interacting protein 1 related
HIST1H2AC histone cluster 1, H2ac
HLA-E major histocompatibility complex, class I, E
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LETMD1 LETM1 domain containing 1
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MAN2A1 mannosidase, alpha, class 2A, member 1
MERTK MER proto-oncogene, tyrosine kinase
MMP7 matrix metallopeptidase 7
MNT MAX network transcriptional repressor
MT2A metallothionein 2A
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NEBL nebulette
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOV nephroblastoma overexpressed
NPY1R neuropeptide Y receptor Y1
OSR2 odd-skipped related transciption factor 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG3 paternally expressed 3
PF4 platelet factor 4
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLBD1 phospholipase B domain containing 1
PLCB4 phospholipase C, beta 4
POSTN periostin, osteoblast specific factor
QPCT glutaminyl-peptide cyclotransferase
RAI2 retinoic acid induced 2
RAP1GAP RAP1 GTPase activating protein
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RGS5 regulator of G-protein signaling 5
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHOQ ras homolog family member Q
RNMT RNA (guanine-7-) methyltransferase
RRAGD Ras-related GTP binding D
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEPP1 selenoprotein P, plasma, 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3YL1 SH3 and SYLF domain containing 1
SIDT2 SID1 transmembrane family, member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD3 SMAD family member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATA20 spermatogenesis associated 20
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STON1 stonin 1
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TMPRSS2 transmembrane protease, serine 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
VCAN versican
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
C3 complement component 3
C4BPA complement component 4 binding protein, alpha
C7 complement component 7
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
DHCR24 24-dehydrocholesterol reductase
DMTF1 cyclin D binding myb-like transcription factor 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ENO1 enolase 1, (alpha)
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
GAL galanin/GMAP prepropeptide
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
GRWD1 glutamate-rich WD repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL13RA2 interleukin 13 receptor, alpha 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF14 kinesin family member 14
LGALS1 lectin, galactoside-binding, soluble, 1
LMO4 LIM domain only 4
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
MAP2K3 mitogen-activated protein kinase kinase 3
MRPS28 mitochondrial ribosomal protein S28
MYCBP MYC binding protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PCNA proliferating cell nuclear antigen
PCTP phosphatidylcholine transfer protein
PDLIM1 PDZ and LIM domain 1
PHGDH phosphoglycerate dehydrogenase
PITX1 paired-like homeodomain 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB5C RAB5C, member RAS oncogene family
RAD51C RAD51 paralog C
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
S100A6 S100 calcium binding protein A6
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCG5 secretogranin V
SDC2 syndecan 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
STK17A serine/threonine kinase 17a
STRA13 stimulated by retinoic acid 13
TAGLN2 transgelin 2
TCF21 transcription factor 21
TMEM45A transmembrane protein 45A
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta