BRD-K59317601_INK-128_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

192 genes differentially expressed following the BRD-K59317601_INK-128_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMOTL2 angiomotin like 2
ANXA4 annexin A4
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BLNK B-cell linker
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC92 coiled-coil domain containing 92
CCND2 cyclin D2
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN1 claudin 1
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CRISP3 cysteine-rich secretory protein 3
CXADR coxsackie virus and adenovirus receptor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DARS aspartyl-tRNA synthetase
DDB2 damage-specific DNA binding protein 2, 48kDa
DEFA5 defensin, alpha 5, Paneth cell-specific
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPP8 dipeptidyl-peptidase 8
ERBB2 erb-b2 receptor tyrosine kinase 2
FHL2 four and a half LIM domains 2
FNBP1 formin binding protein 1
GALC galactosylceramidase
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
HNMT histamine N-methyltransferase
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP7 insulin-like growth factor binding protein 7
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LGALS3 lectin, galactoside-binding, soluble, 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MBNL2 muscleblind-like splicing regulator 2
MID1 midline 1
MMP7 matrix metallopeptidase 7
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
PCCA propionyl CoA carboxylase, alpha polypeptide
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PERP PERP, TP53 apoptosis effector
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPL periplakin
PSPH phosphoserine phosphatase
PYCARD PYD and CARD domain containing
QARS glutaminyl-tRNA synthetase
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RNASE6 ribonuclease, RNase A family, k6
RND3 Rho family GTPase 3
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RSL1D1 ribosomal L1 domain containing 1
S100A14 S100 calcium binding protein A14
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SH3YL1 SH3 and SYLF domain containing 1
SLC16A6 solute carrier family 16, member 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STOM stomatin
SYCP2 synaptonemal complex protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TGM2 transglutaminase 2
TMC5 transmembrane channel-like 5
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPP1 tripeptidyl peptidase I
TRAF5 TNF receptor-associated factor 5
TSPAN4 tetraspanin 4
VCAN versican
VCL vinculin
YBX3 Y box binding protein 3
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AQP1 aquaporin 1 (Colton blood group)
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
BZW2 basic leucine zipper and W2 domains 2
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBR1 carbonyl reductase 1
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CLIC5 chloride intracellular channel 5
CSRP2 cysteine and glycine-rich protein 2
CYCS cytochrome c, somatic
DCK deoxycytidine kinase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DMTF1 cyclin D binding myb-like transcription factor 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZR ezrin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
GPM6B glycoprotein M6B
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KIF14 kinesin family member 14
LMO4 LIM domain only 4
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NMU neuromedin U
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OAZ1 ornithine decarboxylase antizyme 1
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM1 PDZ and LIM domain 1
PHGDH phosphoglycerate dehydrogenase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POU4F1 POU class 4 homeobox 1
PRDX2 peroxiredoxin 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB5C RAB5C, member RAS oncogene family
RAD51C RAD51 paralog C
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RHOB ras homolog family member B
SDC2 syndecan 2
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLPI secretory leukocyte peptidase inhibitor
TAGLN2 transgelin 2
TCTN1 tectonic family member 1
TK1 thymidine kinase 1, soluble
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TUBB3 tubulin, beta 3 class III
UBE2S ubiquitin-conjugating enzyme E2S
VAMP8 vesicle-associated membrane protein 8
VGLL4 vestigial-like family member 4
WT1 Wilms tumor 1
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta