BRD-K59317601_INK-128_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K59317601_INK-128_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
AGA aspartylglucosaminidase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARHGAP29 Rho GTPase activating protein 29
ATP9A ATPase, class II, type 9A
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C2CD5 C2 calcium-dependent domain containing 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLEC2B C-type lectin domain family 2, member B
CP ceruloplasmin (ferroxidase)
CTSA cathepsin A
CYBA cytochrome b-245, alpha polypeptide
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNM1 dynamin 1
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EFNA1 ephrin-A1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ETV5 ets variant 5
FAM134A family with sequence similarity 134, member A
FBP1 fructose-1,6-bisphosphatase 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FZD6 frizzled class receptor 6
GALC galactosylceramidase
GDF15 growth differentiation factor 15
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX1 glutathione peroxidase 1
GRN granulin
GSTT1 glutathione S-transferase theta 1
HIST3H2A histone cluster 3, H2a
HLA-B major histocompatibility complex, class I, B
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HNMT histamine N-methyltransferase
HOMER3 homer scaffolding protein 3
IRS2 insulin receptor substrate 2
KLF2 Kruppel-like factor 2
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LY75 lymphocyte antigen 75
LY96 lymphocyte antigen 96
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MEIS1 Meis homeobox 1
MGLL monoglyceride lipase
MTMR11 myotubularin related protein 11
MVP major vault protein
MX2 MX dynamin-like GTPase 2
MYLK myosin light chain kinase
NID1 nidogen 1
NID2 nidogen 2 (osteonidogen)
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PDZK1IP1 PDZK1 interacting protein 1
PLA2G16 phospholipase A2, group XVI
PLSCR3 phospholipid scramblase 3
PLSCR4 phospholipid scramblase 4
PPAP2C phosphatidic acid phosphatase type 2C
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SEPT10 septin 10
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFF3 trefoil factor 3 (intestinal)
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TMEM14A transmembrane protein 14A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UBE3B ubiquitin protein ligase E3B
VNN1 vanin 1
WDR13 WD repeat domain 13
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ADK adenosine kinase
CCNB2 cyclin B2
CCND2 cyclin D2
CDC20 cell division cycle 20
CEP57 centrosomal protein 57kDa
CPE carboxypeptidase E
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FHL1 four and a half LIM domains 1
FKBP5 FK506 binding protein 5
GRWD1 glutamate-rich WD repeat containing 1
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NPEPL1 aminopeptidase-like 1
NT5DC2 5'-nucleotidase domain containing 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDLIM1 PDZ and LIM domain 1
PGAM1 phosphoglycerate mutase 1 (brain)
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD23B RAD23 homolog B (S. cerevisiae)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TGFBI transforming growth factor, beta-induced, 68kDa
TM9SF2 transmembrane 9 superfamily member 2
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
XPO7 exportin 7