BRD-K59317601_INK-128_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K59317601_INK-128_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ANXA5 annexin A5
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
ASPN asporin
C10ORF10 chromosome 10 open reading frame 10
CAPN2 calpain 2, (m/II) large subunit
CFH complement factor H
CLEC2B C-type lectin domain family 2, member B
CP ceruloplasmin (ferroxidase)
CST1 cystatin SN
CST4 cystatin S
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EPHA3 EPH receptor A3
ETV1 ets variant 1
FGFR1 fibroblast growth factor receptor 1
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
GLRX glutaredoxin (thioltransferase)
GOLM1 golgi membrane protein 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HOXB6 homeobox B6
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IER2 immediate early response 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP1 insulin-like growth factor binding protein 1
IL6ST interleukin 6 signal transducer
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
KRT18 keratin 18, type I
LEF1 lymphoid enhancer-binding factor 1
LPP LIM domain containing preferred translocation partner in lipoma
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT2A metallothionein 2A
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MYO6 myosin VI
MYOF myoferlin
NAV2 neuron navigator 2
NNMT nicotinamide N-methyltransferase
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G16 phospholipase A2, group XVI
PLS3 plastin 3
PPAP2C phosphatidic acid phosphatase type 2C
PROS1 protein S (alpha)
RND3 Rho family GTPase 3
RPS27L ribosomal protein S27-like
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC22A18 solute carrier family 22, member 18
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TM9SF3 transmembrane 9 superfamily member 3
TPM1 tropomyosin 1 (alpha)
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
VCL vinculin
ZBTB16 zinc finger and BTB domain containing 16
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AQP3 aquaporin 3 (Gill blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BIRC5 baculoviral IAP repeat containing 5
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNE1 cyclin E1
CDK1 cyclin-dependent kinase 1
CKAP4 cytoskeleton-associated protein 4
CLCA2 chloride channel accessory 2
CLIC3 chloride intracellular channel 3
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
DACH1 dachshund family transcription factor 1
DAPK1 death-associated protein kinase 1
ELP5 elongator acetyltransferase complex subunit 5
FABP7 fatty acid binding protein 7, brain
FBN2 fibrillin 2
FGFBP1 fibroblast growth factor binding protein 1
FHL1 four and a half LIM domains 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
GPM6B glycoprotein M6B
GRWD1 glutamate-rich WD repeat containing 1
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT13 keratin 13, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LTF lactotransferrin
LYZ lysozyme
MAL mal, T-cell differentiation protein
MB myoglobin
MCAM melanoma cell adhesion molecule
MREG melanoregulin
NEB nebulin
NEBL nebulette
OPN3 opsin 3
P3H2 prolyl 3-hydroxylase 2
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PKP1 plakophilin 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RAD51C RAD51 paralog C
RYR1 ryanodine receptor 1 (skeletal)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLN sarcolipin
SLPI secretory leukocyte peptidase inhibitor
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
TNIP1 TNFAIP3 interacting protein 1
TNNT1 troponin T type 1 (skeletal, slow)
TRIM16 tripartite motif containing 16
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
TTN titin
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
WASF1 WAS protein family, member 1
WNT5A wingless-type MMTV integration site family, member 5A