BRD-K59317601_INK-128_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K59317601_INK-128_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASS1 argininosuccinate synthase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BRD4 bromodomain containing 4
BSG basigin (Ok blood group)
C6ORF48 chromosome 6 open reading frame 48
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CD52 CD52 molecule
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CTSD cathepsin D
DEPTOR DEP domain containing MTOR-interacting protein
DUSP6 dual specificity phosphatase 6
EHD2 EH-domain containing 2
GRN granulin
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTA4H leukotriene A4 hydrolase
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MFGE8 milk fat globule-EGF factor 8 protein
MTA1 metastasis associated 1
NFIL3 nuclear factor, interleukin 3 regulated
NQO1 NAD(P)H dehydrogenase, quinone 1
PDGFC platelet derived growth factor C
PERP PERP, TP53 apoptosis effector
PRSS8 protease, serine, 8
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS10 regulator of G-protein signaling 10
RPL36 ribosomal protein L36
S100P S100 calcium binding protein P
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SYT1 synaptotagmin I
TKT transketolase
TP53 tumor protein p53
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATAD2 ATPase family, AAA domain containing 2
BCHE butyrylcholinesterase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CFH complement factor H
CSRP2 cysteine and glycine-rich protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
DDIT4 DNA-damage-inducible transcript 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FXYD6 FXYD domain containing ion transport regulator 6
GFAP glial fibrillary acidic protein
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
GYG1 glycogenin 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXB6 homeobox B6
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IGFBP3 insulin-like growth factor binding protein 3
KIAA0226L KIAA0226-like
KRT15 keratin 15, type I
LTF lactotransferrin
MT1M metallothionein 1M
MTERF3 mitochondrial transcription termination factor 3
MYCBP MYC binding protein
NES nestin
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOP2 NOP2 nucleolar protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM1 PDZ and LIM domain 1
PLP1 proteolipid protein 1
PLTP phospholipid transfer protein
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKCA protein kinase C, alpha
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PUF60 poly-U binding splicing factor 60KDa
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RGS2 regulator of G-protein signaling 2
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A4 S100 calcium binding protein A4
S100B S100 calcium binding protein B
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SPON1 spondin 1, extracellular matrix protein
TACSTD2 tumor-associated calcium signal transducer 2
TMEM100 transmembrane protein 100
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNC tenascin C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28