BRD-K59317601_INK-128_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K59317601_INK-128_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP9A ATPase, class II, type 9A
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BGN biglycan
C6ORF48 chromosome 6 open reading frame 48
CCL13 chemokine (C-C motif) ligand 13
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL8A2 collagen, type VIII, alpha 2
COLEC12 collectin sub-family member 12
CRELD2 cysteine-rich with EGF-like domains 2
CTGF connective tissue growth factor
CTSK cathepsin K
DARS aspartyl-tRNA synthetase
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP6 dual specificity phosphatase 6
ERAP1 endoplasmic reticulum aminopeptidase 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F5 coagulation factor V (proaccelerin, labile factor)
FAR2 fatty acyl CoA reductase 2
FBN1 fibrillin 1
FERMT1 fermitin family member 1
FOXN3 forkhead box N3
FST follistatin
GALC galactosylceramidase
GAS6 growth arrest-specific 6
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGHD immunoglobulin heavy constant delta
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBA inhibin, beta A
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ISOC1 isochorismatase domain containing 1
ITGA6 integrin, alpha 6
KDSR 3-ketodihydrosphingosine reductase
KLF5 Kruppel-like factor 5 (intestinal)
KRT19 keratin 19, type I
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100272216 uncharacterized LOC100272216
LTA4H leukotriene A4 hydrolase
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2C1 mannosidase, alpha, class 2C, member 1
MANSC1 MANSC domain containing 1
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MCTP1 multiple C2 domains, transmembrane 1
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
MYOF myoferlin
NELL2 NEL-like 2 (chicken)
NET1 neuroepithelial cell transforming 1
NKX2-2 NK2 homeobox 2
NPDC1 neural proliferation, differentiation and control, 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NSG1 neuron specific gene family member 1
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
OXA1L oxidase (cytochrome c) assembly 1-like
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PDLIM1 PDZ and LIM domain 1
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PER2 period circadian clock 2
PERP PERP, TP53 apoptosis effector
PGLS 6-phosphogluconolactonase
PHF3 PHD finger protein 3
PLCB4 phospholipase C, beta 4
PLSCR3 phospholipid scramblase 3
PLXNB2 plexin B2
PPA1 pyrophosphatase (inorganic) 1
PSD3 pleckstrin and Sec7 domain containing 3
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RPL36 ribosomal protein L36
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SAMD4A sterile alpha motif domain containing 4A
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SH3YL1 SH3 and SYLF domain containing 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
SVIL supervillin
SYNJ2 synaptojanin 2
TAPBPL TAP binding protein-like
TCEAL4 transcription elongation factor A (SII)-like 4
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOX thymocyte selection-associated high mobility group box
TPM1 tropomyosin 1 (alpha)
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
TSPO translocator protein (18kDa)
TTC3 tetratricopeptide repeat domain 3
TYMP thymidine phosphorylase
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALDOC aldolase C, fructose-bisphosphate
AQP3 aquaporin 3 (Gill blood group)
BCHE butyrylcholinesterase
C7 complement component 7
CCND3 cyclin D3
CD320 CD320 molecule
CDC25A cell division cycle 25A
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRYAB crystallin, alpha B
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSE dermatan sulfate epimerase
EIF5A eukaryotic translation initiation factor 5A
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPHA3 EPH receptor A3
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GCLM glutamate-cysteine ligase, modifier subunit
GPRC5C G protein-coupled receptor, class C, group 5, member C
GSTA1 glutathione S-transferase alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IL32 interleukin 32
INSIG1 insulin induced gene 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
LCN2 lipocalin 2
LMO4 LIM domain only 4
MAL mal, T-cell differentiation protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
NR2F2 nuclear receptor subfamily 2, group F, member 2
OSBPL8 oxysterol binding protein-like 8
PDZK1 PDZ domain containing 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAM1 phosphoglycerate mutase 1 (brain)
PHGDH phosphoglycerate dehydrogenase
PKM pyruvate kinase, muscle
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTGDS prostaglandin D2 synthase 21kDa (brain)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SOSTDC1 sclerostin domain containing 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STK17A serine/threonine kinase 17a
TCTN1 tectonic family member 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TSPAN12 tetraspanin 12
TUBG1 tubulin, gamma 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZFP36L1 ZFP36 ring finger protein-like 1