BRD-K59273480_PROPENTOFYLLINE_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K59273480_PROPENTOFYLLINE_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD24 CD24 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLIC5 chloride intracellular channel 5
COL10A1 collagen, type X, alpha 1
DCN decorin
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
EXT1 exostosin glycosyltransferase 1
FLT1 fms-related tyrosine kinase 1
GIMAP4 GTPase, IMAP family member 4
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGF2R insulin-like growth factor 2 receptor
MMP1 matrix metallopeptidase 1
MTSS1 metastasis suppressor 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
P3H2 prolyl 3-hydroxylase 2
PKP2 plakophilin 2
PLN phospholamban
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBM34 RNA binding motif protein 34
RCAN2 regulator of calcineurin 2
S100A8 S100 calcium binding protein A8
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SRGN serglycin
STON1 stonin 1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TAGLN transgelin
TESK1 testis-specific kinase 1
TMSB15A thymosin beta 15a
TMX4 thioredoxin-related transmembrane protein 4
TTC39A tetratricopeptide repeat domain 39A
VEGFA vascular endothelial growth factor A
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BZW2 basic leucine zipper and W2 domains 2
C1S complement component 1, s subcomponent
C6ORF48 chromosome 6 open reading frame 48
CCL19 chemokine (C-C motif) ligand 19
CCR7 chemokine (C-C motif) receptor 7
CDCA4 cell division cycle associated 4
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSC cathepsin C
CXCL5 chemokine (C-X-C motif) ligand 5
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EIF4A3 eukaryotic translation initiation factor 4A3
F3 coagulation factor III (thromboplastin, tissue factor)
GRWD1 glutamate-rich WD repeat containing 1
IL6 interleukin 6
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM5D lysine (K)-specific demethylase 5D
KRT7 keratin 7, type II
KYNU kynureninase
MGLL monoglyceride lipase
NFIB nuclear factor I/B
NPC2 Niemann-Pick disease, type C2
OAT ornithine aminotransferase
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POPDC3 popeye domain containing 3
PROM1 prominin 1
RPL36 ribosomal protein L36
S100A11 S100 calcium binding protein A11
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TIAM1 T-cell lymphoma invasion and metastasis 1
TM9SF3 transmembrane 9 superfamily member 3
TNC tenascin C
TRBC1 T cell receptor beta constant 1
TSPAN13 tetraspanin 13