BRD-K59184148_SB-216763_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K59184148_SB-216763_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMDHD2 amidohydrolase domain containing 2
CD24 CD24 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CREB3L2 cAMP responsive element binding protein 3-like 2
CRYAB crystallin, alpha B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
EMP3 epithelial membrane protein 3
EVL Enah/Vasp-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FRZB frizzled-related protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HSPB8 heat shock 22kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IL13RA2 interleukin 13 receptor, alpha 2
KLK5 kallikrein-related peptidase 5
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LOC100505650 uncharacterized LOC100505650
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MPPED2 metallophosphoesterase domain containing 2
OLFM4 olfactomedin 4
PELI1 pellino E3 ubiquitin protein ligase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RPL39L ribosomal protein L39-like
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAMBP STAM binding protein
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VGLL1 vestigial-like family member 1
WASF3 WAS protein family, member 3

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AMIGO2 adhesion molecule with Ig-like domain 2
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL5 chemokine (C-C motif) ligand 5
CD52 CD52 molecule
COL10A1 collagen, type X, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CST1 cystatin SN
CTSD cathepsin D
CXCL9 chemokine (C-X-C motif) ligand 9
DEGS1 delta(4)-desaturase, sphingolipid 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
EFNB2 ephrin-B2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA4 EPH receptor A4
FBXO28 F-box protein 28
FPGS folylpolyglutamate synthase
FTH1 ferritin, heavy polypeptide 1
GAS1 growth arrest-specific 1
GMFG glia maturation factor, gamma
GOLM1 golgi membrane protein 1
GPATCH2 G patch domain containing 2
GREM1 gremlin 1, DAN family BMP antagonist
HMG20B high mobility group 20B
HOPX HOP homeobox
HOXB7 homeobox B7
HSPA4 heat shock 70kDa protein 4
IGKV1-5 immunoglobulin kappa variable 1-5
IL7R interleukin 7 receptor
IRS2 insulin receptor substrate 2
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LOX lysyl oxidase
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
NELL2 NEL-like 2 (chicken)
NNMT nicotinamide N-methyltransferase
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUAK1 NUAK family, SNF1-like kinase, 1
NVL nuclear VCP-like
NXN nucleoredoxin
PHLDA2 pleckstrin homology-like domain, family A, member 2
POSTN periostin, osteoblast specific factor
PSD3 pleckstrin and Sec7 domain containing 3
RGS1 regulator of G-protein signaling 1
SCG5 secretogranin V
SELENBP1 selenium binding protein 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX11 SRY (sex determining region Y)-box 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
THBS1 thrombospondin 1
TMEM97 transmembrane protein 97
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
XIST X inactive specific transcript (non-protein coding)