BRD-K58853583_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

257 genes differentially expressed following the BRD-K58853583_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ADAMDEC1 ADAM-like, decysin 1
AKIRIN1 akirin 1
ANKHD1 ankyrin repeat and KH domain containing 1
ARG1 arginase 1
ARMC8 armadillo repeat containing 8
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BBX bobby sox homolog (Drosophila)
BCL2A1 BCL2-related protein A1
BTG3 BTG family, member 3
CAMP cathelicidin antimicrobial peptide
CD24 CD24 molecule
CD46 CD46 molecule, complement regulatory protein
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
CLP1 cleavage and polyadenylation factor I subunit 1
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DEFA4 defensin, alpha 4, corticostatin
DUSP2 dual specificity phosphatase 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GREB1 growth regulation by estrogen in breast cancer 1
GSN gelsolin
HES1 hes family bHLH transcription factor 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB2 homeobox B2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFRD1 interferon-related developmental regulator 1
IGLL1 immunoglobulin lambda-like polypeptide 1
ING2 inhibitor of growth family, member 2
JAG1 jagged 1
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LCN2 lipocalin 2
LEPROT leptin receptor overlapping transcript
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MLF1 myeloid leukemia factor 1
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
OLFM4 olfactomedin 4
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PELI1 pellino E3 ubiquitin protein ligase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRNP prion protein
QPCT glutaminyl-peptide cyclotransferase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGCC regulator of cell cycle
RNF11 ring finger protein 11
RYBP RING1 and YY1 binding protein
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC35F2 solute carrier family 35, member F2
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
SRGN serglycin
STK17B serine/threonine kinase 17b
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TRA2B transformer 2 beta homolog (Drosophila)
TWSG1 twisted gastrulation BMP signaling modulator 1
TXNIP thioredoxin interacting protein
UBE2N ubiquitin-conjugating enzyme E2N
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAMP3 vesicle-associated membrane protein 3
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
AKAP12 A kinase (PRKA) anchor protein 12
AKAP9 A kinase (PRKA) anchor protein 9
ANKRD10 ankyrin repeat domain 10
ANKRD17 ankyrin repeat domain 17
ANKRD28 ankyrin repeat domain 28
ANKRD36B ankyrin repeat domain 36B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASS1 argininosuccinate synthase 1
ASXL2 additional sex combs like transcriptional regulator 2
ATR ATR serine/threonine kinase
AVL9 AVL9 homolog (S. cerevisiase)
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BPIFA1 BPI fold containing family A, member 1
BRCA1 breast cancer 1, early onset
C1RL complement component 1, r subcomponent-like
C2CD2 C2 calcium-dependent domain containing 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK12 cyclin-dependent kinase 12
CDK14 cyclin-dependent kinase 14
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEMIP cell migration inducing protein, hyaluronan binding
CEP170 centrosomal protein 170kDa
CEP55 centrosomal protein 55kDa
CFB complement factor B
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COA3 cytochrome c oxidase assembly factor 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIXDC1 DIX domain containing 1
DMXL2 Dmx-like 2
DST dystonin
EDRF1 erythroid differentiation regulatory factor 1
ELMO1 engulfment and cell motility 1
FAM134B family with sequence similarity 134, member B
FAM208A family with sequence similarity 208, member A
FAM216A family with sequence similarity 216, member A
FBXW2 F-box and WD repeat domain containing 2
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FOLR1 folate receptor 1 (adult)
FOXD1 forkhead box D1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLS glutaminase
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GSAP gamma-secretase activating protein
HOXC6 homeobox C6
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGLV2-23 immunoglobulin lambda variable 2-23
IRS2 insulin receptor substrate 2
KIF14 kinesin family member 14
KRIT1 KRIT1, ankyrin repeat containing
KRT7 keratin 7, type II
LACTB2 lactamase, beta 2
LAMB1 laminin, beta 1
LGALS8 lectin, galactoside-binding, soluble, 8
LOC100272216 uncharacterized LOC100272216
LPCAT1 lysophosphatidylcholine acyltransferase 1
LYST lysosomal trafficking regulator
MACF1 microtubule-actin crosslinking factor 1
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
METTL3 methyltransferase like 3
MXRA7 matrix-remodelling associated 7
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NEFL neurofilament, light polypeptide
NMT1 N-myristoyltransferase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NREP neuronal regeneration related protein
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDS5A PDS5 cohesin associated factor A
PFKP phosphofructokinase, platelet
PHIP pleckstrin homology domain interacting protein
PIKFYVE phosphoinositide kinase, FYVE finger containing
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLS1 plastin 1
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POT1 protection of telomeres 1
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R10 protein phosphatase 1, regulatory subunit 10
PROM1 prominin 1
PUS7 pseudouridylate synthase 7 (putative)
RAB29 RAB29, member RAS oncogene family
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBM15B RNA binding motif protein 15B
RBPMS RNA binding protein with multiple splicing
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL31 ribosomal protein L31
SENP6 SUMO1/sentrin specific peptidase 6
SETX senataxin
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SPATS2L spermatogenesis associated, serine-rich 2-like
SPG11 spastic paraplegia 11 (autosomal recessive)
STAR steroidogenic acute regulatory protein
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D31 TBC1 domain family, member 31
TCF12 transcription factor 12
TENM1 teneurin transmembrane protein 1
TFPI2 tissue factor pathway inhibitor 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOM1L1 target of myb1 (chicken)-like 1
TRIP6 thyroid hormone receptor interactor 6
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TTC28 tetratricopeptide repeat domain 28
UBE3C ubiquitin protein ligase E3C
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
VCAN versican
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF451 zinc finger protein 451
ZNF638 zinc finger protein 638