BRD-K58772419_AZD-6482_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K58772419_AZD-6482_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
BASP1 brain abundant, membrane attached signal protein 1
C7 complement component 7
CADPS2 Ca++-dependent secretion activator 2
DRAM1 DNA-damage regulated autophagy modulator 1
DSG2 desmoglein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
KIAA1033 KIAA1033
LAMP2 lysosomal-associated membrane protein 2
MAP7 microtubule-associated protein 7
SRGN serglycin
STAR steroidogenic acute regulatory protein
TIMP1 TIMP metallopeptidase inhibitor 1
TRIB2 tribbles pseudokinase 2
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASPN asporin
BACE2 beta-site APP-cleaving enzyme 2
BCHE butyrylcholinesterase
BTG3 BTG family, member 3
CA12 carbonic anhydrase XII
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLEC2B C-type lectin domain family 2, member B
COL6A1 collagen, type VI, alpha 1
DEFB1 defensin, beta 1
DMD dystrophin
EDN3 endothelin 3
EMP1 epithelial membrane protein 1
EPHA3 EPH receptor A3
FZD7 frizzled class receptor 7
GPR88 G protein-coupled receptor 88
HIST1H4C histone cluster 1, H4c
HLA-B major histocompatibility complex, class I, B
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
IGL immunoglobulin lambda locus
JADE2 jade family PHD finger 2
KRT6B keratin 6B, type II
LIMS1 LIM and senescent cell antigen-like domains 1
LPL lipoprotein lipase
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MXRA5 matrix-remodelling associated 5
MYLK myosin light chain kinase
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
POSTN periostin, osteoblast specific factor
SATB1 SATB homeobox 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TPBG trophoblast glycoprotein