BRD-K58679021_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K58679021_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AMDHD2 amidohydrolase domain containing 2
ANO10 anoctamin 10
AXL AXL receptor tyrosine kinase
BBX bobby sox homolog (Drosophila)
CA12 carbonic anhydrase XII
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
COL18A1 collagen, type XVIII, alpha 1
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTSZ cathepsin Z
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
FABP7 fatty acid binding protein 7, brain
FOLR1 folate receptor 1 (adult)
IFITM1 interferon induced transmembrane protein 1
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
LAMP3 lysosomal-associated membrane protein 3
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOV nephroblastoma overexpressed
PEG3 paternally expressed 3
PLAGL1 pleiomorphic adenoma gene-like 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKCQ protein kinase C, theta
RRAGD Ras-related GTP binding D
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
THBS1 thrombospondin 1
TRA2A transformer 2 alpha homolog (Drosophila)
VCAM1 vascular cell adhesion molecule 1
XIST X inactive specific transcript (non-protein coding)
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
CDC42 cell division cycle 42
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLPTM1 cleft lip and palate associated transmembrane protein 1
CXADR coxsackie virus and adenovirus receptor
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FXYD3 FXYD domain containing ion transport regulator 3
GPX2 glutathione peroxidase 2
GRB7 growth factor receptor-bound protein 7
HACD3 3-hydroxyacyl-CoA dehydratase 3
IL17RB interleukin 17 receptor B
LDLR low density lipoprotein receptor
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
PAM peptidylglycine alpha-amidating monooxygenase
PDHX pyruvate dehydrogenase complex, component X
PHLDA2 pleckstrin homology-like domain, family A, member 2
PRSS8 protease, serine, 8
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAD23B RAD23 homolog B (S. cerevisiae)
RND3 Rho family GTPase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
TJP2 tight junction protein 2