BRD-K58674774_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K58674774_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AQP3 aquaporin 3 (Gill blood group)
BTG2 BTG family, member 2
C3 complement component 3
CLDN3 claudin 3
COLEC12 collectin sub-family member 12
CXCL13 chemokine (C-X-C motif) ligand 13
FBLN1 fibulin 1
GAL galanin/GMAP prepropeptide
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
HCP5 HLA complex P5 (non-protein coding)
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOPX HOP homeobox
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
LAMA4 laminin, alpha 4
LAPTM5 lysosomal protein transmembrane 5
LOC100505650 uncharacterized LOC100505650
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MMP7 matrix metallopeptidase 7
MPPED2 metallophosphoesterase domain containing 2
P3H2 prolyl 3-hydroxylase 2
P4HB prolyl 4-hydroxylase, beta polypeptide
PLBD1 phospholipase B domain containing 1
PPARG peroxisome proliferator-activated receptor gamma
RGS1 regulator of G-protein signaling 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCD5 stearoyl-CoA desaturase 5
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
ZEB1 zinc finger E-box binding homeobox 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ACTN1 actinin, alpha 1
ADI1 acireductone dioxygenase 1
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BEX1 brain expressed, X-linked 1
CBR3 carbonyl reductase 3
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
COMP cartilage oligomeric matrix protein
CREB1 cAMP responsive element binding protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DPYSL2 dihydropyrimidinase-like 2
ELF1 E74-like factor 1 (ets domain transcription factor)
FADS1 fatty acid desaturase 1
FLNA filamin A, alpha
FN1 fibronectin 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPX3 glutathione peroxidase 3
GPX7 glutathione peroxidase 7
GSTM3 glutathione S-transferase mu 3 (brain)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSPH1 heat shock 105kDa/110kDa protein 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MFAP5 microfibrillar associated protein 5
MT2A metallothionein 2A
NAP1L1 nucleosome assembly protein 1-like 1
NKTR natural killer cell triggering receptor
PABPC3 poly(A) binding protein, cytoplasmic 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PNMA2 paraneoplastic Ma antigen 2
PRRC2C proline-rich coiled-coil 2C
RDX radixin
RNF13 ring finger protein 13
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STXBP2 syntaxin binding protein 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TOR1A torsin family 1, member A (torsin A)
TSPAN4 tetraspanin 4
WASF3 WAS protein family, member 3
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZC3H13 zinc finger CCCH-type containing 13