BRD-K58306044_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K58306044_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMD1 adenosylmethionine decarboxylase 1
AREG amphiregulin
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
CALML5 calmodulin-like 5
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD47 CD47 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLIC4 chloride intracellular channel 4
CTSH cathepsin H
CTSS cathepsin S
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
EREG epiregulin
EZR ezrin
FGG fibrinogen gamma chain
FZD5 frizzled class receptor 5
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGA2 high mobility group AT-hook 2
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
IL6ST interleukin 6 signal transducer
JCHAIN joining chain of multimeric IgA and IgM
KIAA1598
KLF9 Kruppel-like factor 9
KLHL9 kelch-like family member 9
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAPT microtubule-associated protein tau
MTSS1 metastasis suppressor 1
MYOF myoferlin
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZK1 PDZ domain containing 1
PEA15 phosphoprotein enriched in astrocytes 15
PER1 period circadian clock 1
PHACTR2 phosphatase and actin regulator 2
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
RCAN2 regulator of calcineurin 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RHOB ras homolog family member B
RPS11 ribosomal protein S11
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMS spermine synthase
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STC2 stanniocalcin 2
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TSC22D3 TSC22 domain family, member 3
TYRP1 tyrosinase-related protein 1
UBE2A ubiquitin-conjugating enzyme E2A
XBP1 X-box binding protein 1
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANKRD10 ankyrin repeat domain 10
BAX BCL2-associated X protein
C9ORF16 chromosome 9 open reading frame 16
CAMP cathelicidin antimicrobial peptide
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK6 cyclin-dependent kinase 6
COG2 component of oligomeric golgi complex 2
COL1A1 collagen, type I, alpha 1
CRISP3 cysteine-rich secretory protein 3
CTTN cortactin
FAM46A family with sequence similarity 46, member A
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FSCN1 fascin actin-bundling protein 1
FSD1 fibronectin type III and SPRY domain containing 1
GALE UDP-galactose-4-epimerase
GOLGA8A golgin A8 family, member A
GPAA1 glycosylphosphatidylinositol anchor attachment 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HTRA1 HtrA serine peptidase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KDM3A lysine (K)-specific demethylase 3A
KRT19 keratin 19, type I
LCN2 lipocalin 2
LYPD1 LY6/PLAUR domain containing 1
MDK midkine (neurite growth-promoting factor 2)
METRN meteorin, glial cell differentiation regulator
NLGN4X neuroligin 4, X-linked
NMU neuromedin U
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDAP1 PDGFA associated protein 1
PDLIM4 PDZ and LIM domain 4
PIH1D1 PIH1 domain containing 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SFRP4 secreted frizzled-related protein 4
SLPI secretory leukocyte peptidase inhibitor
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TRIM2 tripartite motif containing 2
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZMYND8 zinc finger, MYND-type containing 8