BRD-K58306044_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K58306044_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
AHNAK AHNAK nucleoprotein
APOH apolipoprotein H (beta-2-glycoprotein I)
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C4BPA complement component 4 binding protein, alpha
C7 complement component 7
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
COL14A1 collagen, type XIV, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
CTH cystathionine gamma-lyase
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GREB1 growth regulation by estrogen in breast cancer 1
HIST1H1C histone cluster 1, H1c
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IER5 immediate early response 5
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
IL7R interleukin 7 receptor
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYRF myelin regulatory factor
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
ODC1 ornithine decarboxylase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RRAD Ras-related associated with diabetes
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAT1 spermidine/spermine N1-acetyltransferase 1
SELE selectin E
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SNX13 sorting nexin 13
SOD2 superoxide dismutase 2, mitochondrial
STC2 stanniocalcin 2
TFRC transferrin receptor
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMPRSS3 transmembrane protease, serine 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TUFT1 tuftelin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WTAP Wilms tumor 1 associated protein
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AMACR alpha-methylacyl-CoA racemase
ASCL1 achaete-scute family bHLH transcription factor 1
CA12 carbonic anhydrase XII
CAPRIN1 cell cycle associated protein 1
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CCNF cyclin F
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLTC clathrin, heavy chain (Hc)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DPYSL2 dihydropyrimidinase-like 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
GTSE1 G-2 and S-phase expressed 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLTF helicase-like transcription factor
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA8 heat shock 70kDa protein 8
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
MEGF9 multiple EGF-like-domains 9
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PROM1 prominin 1
S100A7 S100 calcium binding protein A7
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPHS1 selenophosphate synthetase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
TBC1D16 TBC1 domain family, member 16
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC3 trafficking protein particle complex 3
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
VCAN versican
VDAC1 voltage-dependent anion channel 1