BRD-K58288048_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K58288048_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
CAPN2 calpain 2, (m/II) large subunit
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRDL1 chordin-like 1
CNPY3 canopy FGF signaling regulator 3
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FOXG1 forkhead box G1
GDF15 growth differentiation factor 15
HIST1H2BG histone cluster 1, H2bg
IER3 immediate early response 3
KIAA1598
KRT19 keratin 19, type I
LDB2 LIM domain binding 2
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PSD3 pleckstrin and Sec7 domain containing 3
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP4 secreted frizzled-related protein 4
SH3YL1 SH3 and SYLF domain containing 1
SHB Src homology 2 domain containing adaptor protein B
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNCAIP synuclein, alpha interacting protein
SYBU syntabulin (syntaxin-interacting)
SYT1 synaptotagmin I
TPD52 tumor protein D52
TPSAB1 tryptase alpha/beta 1
TSC22D3 TSC22 domain family, member 3
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD59 CD59 molecule, complement regulatory protein
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
GBP1 guanylate binding protein 1, interferon-inducible
GRWD1 glutamate-rich WD repeat containing 1
HDDC2 HD domain containing 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
KRT17 keratin 17, type I
LAP3 leucine aminopeptidase 3
NUP98 nucleoporin 98kDa
OXTR oxytocin receptor
PDGFA platelet-derived growth factor alpha polypeptide
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPIF peptidylprolyl isomerase F
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SFN stratifin
STAT1 signal transducer and activator of transcription 1, 91kDa
TBX2 T-box 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
ZIC1 Zic family member 1