BRD-K58288048_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K58288048_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CALR calreticulin
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CPA3 carboxypeptidase A3 (mast cell)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DSP desmoplakin
FADS1 fatty acid desaturase 1
FAM63A family with sequence similarity 63, member A
GSN gelsolin
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IER3 immediate early response 3
IL1B interleukin 1, beta
KRT18 keratin 18, type I
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
RHOB ras homolog family member B
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFN stratifin
SOX9 SRY (sex determining region Y)-box 9
TCTA T-cell leukemia translocation altered
TM4SF1 transmembrane 4 L six family member 1
TPD52L1 tumor protein D52-like 1
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
WIF1 WNT inhibitory factor 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BLCAP bladder cancer associated protein
CAST calpastatin
CDC20 cell division cycle 20
CELF2 CUGBP, Elav-like family member 2
COL5A2 collagen, type V, alpha 2
CTPS1 CTP synthase 1
GAS1 growth arrest-specific 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
NOP2 NOP2 nucleolar protein
PEG10 paternally expressed 10
PEG3 paternally expressed 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TCF4 transcription factor 4
TMPRSS3 transmembrane protease, serine 3