BRD-K57457519_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K57457519_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CLU clusterin
CREB3L2 cAMP responsive element binding protein 3-like 2
DDHD2 DDHD domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
EIF3L eukaryotic translation initiation factor 3, subunit L
FKBP10 FK506 binding protein 10, 65 kDa
FN1 fibronectin 1
GBP2 guanylate binding protein 2, interferon-inducible
HEBP1 heme binding protein 1
HMOX1 heme oxygenase 1
KLHL21 kelch-like family member 21
LTBP3 latent transforming growth factor beta binding protein 3
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
PDLIM1 PDZ and LIM domain 1
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PLTP phospholipid transfer protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SELE selectin E
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SRPX sushi-repeat containing protein, X-linked
TM4SF1 transmembrane 4 L six family member 1
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF5 activating transcription factor 5
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CDC20 cell division cycle 20
CXCL14 chemokine (C-X-C motif) ligand 14
DHCR24 24-dehydrocholesterol reductase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EMP2 epithelial membrane protein 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FOLR1 folate receptor 1 (adult)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
HDGFRP3 hepatoma-derived growth factor, related protein 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
JCHAIN joining chain of multimeric IgA and IgM
KRT15 keratin 15, type I
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MELK maternal embryonic leucine zipper kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PON3 paraoxonase 3
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RRM2 ribonucleotide reductase M2
SELT selenoprotein T
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPINK5 serine peptidase inhibitor, Kazal type 5
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
TACSTD2 tumor-associated calcium signal transducer 2
TMPO thymopoietin
TUBB4B tubulin, beta 4B class IVb
ZWINT ZW10 interacting kinetochore protein