BRD-K57309821_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K57309821_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ARMCX2 armadillo repeat containing, X-linked 2
BHLHE41 basic helix-loop-helix family, member e41
BID BH3 interacting domain death agonist
CECR1 cat eye syndrome chromosome region, candidate 1
CHN2 chimerin 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL14 chemokine (C-X-C motif) ligand 14
DHCR24 24-dehydrocholesterol reductase
DMXL2 Dmx-like 2
DPP4 dipeptidyl-peptidase 4
EDNRB endothelin receptor type B
EI24 etoposide induced 2.4
ELOVL2 ELOVL fatty acid elongase 2
FABP7 fatty acid binding protein 7, brain
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GUSBP11 glucuronidase, beta pseudogene 11
HOXC6 homeobox C6
IGFBP5 insulin-like growth factor binding protein 5
IRS2 insulin receptor substrate 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
LMO2 LIM domain only 2 (rhombotin-like 1)
LY96 lymphocyte antigen 96
MAPT microtubule-associated protein tau
MATN2 matrilin 2
MPPED2 metallophosphoesterase domain containing 2
MZB1 marginal zone B and B1 cell-specific protein
NANOG Nanog homeobox
NLGN4X neuroligin 4, X-linked
NPY1R neuropeptide Y receptor Y1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFD platelet derived growth factor D
PEG3 paternally expressed 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTX3 pentraxin 3, long
PXDN peroxidasin
RRAGD Ras-related GTP binding D
SCGB2A1 secretoglobin, family 2A, member 1
SH2B3 SH2B adaptor protein 3
SLC43A3 solute carrier family 43, member 3
STAR steroidogenic acute regulatory protein
TMEM176B transmembrane protein 176B
TMEM255A transmembrane protein 255A
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
VCAN versican

decreased expression

Symbol Name
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
APOLD1 apolipoprotein L domain containing 1
ATP9A ATPase, class II, type 9A
CD24 CD24 molecule
CDK6 cyclin-dependent kinase 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CLU clusterin
COL4A6 collagen, type IV, alpha 6
CXCL13 chemokine (C-X-C motif) ligand 13
DSTN destrin (actin depolymerizing factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EZR ezrin
FERMT1 fermitin family member 1
FGFR2 fibroblast growth factor receptor 2
FOLR1 folate receptor 1 (adult)
GATA6 GATA binding protein 6
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IL17RB interleukin 17 receptor B
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
MAP7 microtubule-associated protein 7
MTCL1 microtubule crosslinking factor 1
MTSS1 metastasis suppressor 1
MYCBP MYC binding protein
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NQO1 NAD(P)H dehydrogenase, quinone 1
PALLD palladin, cytoskeletal associated protein
PAWR PRKC, apoptosis, WT1, regulator
PERP PERP, TP53 apoptosis effector
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLSCR3 phospholipid scramblase 3
PRKCZ protein kinase C, zeta
PRSS21 protease, serine, 21 (testisin)
RHOB ras homolog family member B
SERINC3 serine incorporator 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMYD3 SET and MYND domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYNGR3 synaptogyrin 3
TPD52 tumor protein D52
VDAC1 voltage-dependent anion channel 1