BRD-K57282030_JW-7-24-1_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K57282030_JW-7-24-1_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADCK3 aarF domain containing kinase 3
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
AREG amphiregulin
CCP110 centriolar coiled coil protein 110kDa
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFI complement factor I
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CTGF connective tissue growth factor
CTSA cathepsin A
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPYC epiphycan
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBN1 fibrillin 1
FHL1 four and a half LIM domains 1
FRZB frizzled-related protein
FSD1 fibronectin type III and SPRY domain containing 1
GMPR guanosine monophosphate reductase
GPRC5B G protein-coupled receptor, class C, group 5, member B
GYPC glycophorin C (Gerbich blood group)
HOXD1 homeobox D1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KLK10 kallikrein-related peptidase 10
LAMA4 laminin, alpha 4
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS4 lectin, galactoside-binding, soluble, 4
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
NID2 nidogen 2 (osteonidogen)
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDGFD platelet derived growth factor D
PTGIS prostaglandin I2 (prostacyclin) synthase
RBKS ribokinase
RCAN2 regulator of calcineurin 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
SRPX sushi-repeat containing protein, X-linked
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STXBP1 syntaxin binding protein 1
TLE4 transducin-like enhancer of split 4
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TXNIP thioredoxin interacting protein
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ADM adrenomedullin
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CALML5 calmodulin-like 5
CDC42SE1 CDC42 small effector 1
CSTA cystatin A (stefin A)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR7 7-dehydrocholesterol reductase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
H2AFZ H2A histone family, member Z
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LTF lactotransferrin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
NCF2 neutrophil cytosolic factor 2
PLIN2 perilipin 2
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SOX9 SRY (sex determining region Y)-box 9
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM45A transmembrane protein 45A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon