BRD-K57282030_JW-7-24-1_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K57282030_JW-7-24-1_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BHLHE41 basic helix-loop-helix family, member e41
CD9 CD9 molecule
CFB complement factor B
CLIC5 chloride intracellular channel 5
CRIP1 cysteine-rich protein 1 (intestinal)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFNA1 ephrin-A1
ETV1 ets variant 1
FABP4 fatty acid binding protein 4, adipocyte
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
GRN granulin
H1FX H1 histone family, member X
HBP1 HMG-box transcription factor 1
INSIG1 insulin induced gene 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
LDLR low density lipoprotein receptor
MAGED2 melanoma antigen family D2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTSS1 metastasis suppressor 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PTX3 pentraxin 3, long
SEPT10 septin 10
SLC38A2 solute carrier family 38, member 2
SQSTM1 sequestosome 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAB1 stabilin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TPP1 tripeptidyl peptidase I
TSPAN12 tetraspanin 12
TSPO translocator protein (18kDa)

decreased expression

Symbol Name
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CD200 CD200 molecule
CDC25A cell division cycle 25A
CDKN3 cyclin-dependent kinase inhibitor 3
CHSY1 chondroitin sulfate synthase 1
CPE carboxypeptidase E
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DDIT4 DNA-damage-inducible transcript 4
ENO2 enolase 2 (gamma, neuronal)
FAS Fas cell surface death receptor
GCH1 GTP cyclohydrolase 1
HEPH hephaestin
HIST1H4C histone cluster 1, H4c
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
MATN2 matrilin 2
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MYB v-myb avian myeloblastosis viral oncogene homolog
NUSAP1 nucleolar and spindle associated protein 1
PCP4 Purkinje cell protein 4
PLAC8 placenta-specific 8
POSTN periostin, osteoblast specific factor
PRC1 protein regulator of cytokinesis 1
PRKCB protein kinase C, beta
PROM1 prominin 1
RAD23B RAD23 homolog B (S. cerevisiae)
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RRM1 ribonucleotide reductase M1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SELL selectin L
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC43A3 solute carrier family 43, member 3
TAGLN transgelin
TESC tescalcin
TSPYL5 TSPY-like 5