BRD-K57282030_JW-7-24-1_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K57282030_JW-7-24-1_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AK4 adenylate kinase 4
AKR1C1 aldo-keto reductase family 1, member C1
ANXA1 annexin A1
ARHGAP29 Rho GTPase activating protein 29
BTG1 B-cell translocation gene 1, anti-proliferative
CCNG2 cyclin G2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CFH complement factor H
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COMP cartilage oligomeric matrix protein
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
FZD7 frizzled class receptor 7
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GRB10 growth factor receptor-bound protein 10
HBP1 HMG-box transcription factor 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
LOX lysyl oxidase
MDK midkine (neurite growth-promoting factor 2)
MFAP5 microfibrillar associated protein 5
NT5E 5'-nucleotidase, ecto (CD73)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RAB2A RAB2A, member RAS oncogene family
RTN1 reticulon 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC38A1 solute carrier family 38, member 1
TFPI2 tissue factor pathway inhibitor 2
THBS4 thrombospondin 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOM1L1 target of myb1 (chicken)-like 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ATP10B ATPase, class V, type 10B
BMP7 bone morphogenetic protein 7
CDC25A cell division cycle 25A
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
DHRS2 dehydrogenase/reductase (SDR family) member 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FXYD3 FXYD domain containing ion transport regulator 3
HCAR3 hydroxycarboxylic acid receptor 3
IL13RA2 interleukin 13 receptor, alpha 2
IL1RN interleukin 1 receptor antagonist
NKX2-2 NK2 homeobox 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
TEX10 testis expressed 10
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSPAN8 tetraspanin 8