BRD-K57282030_JW-7-24-1_HS578T_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K57282030_JW-7-24-1_HS578T_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ADRB2 adrenoceptor beta 2, surface
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CCL19 chemokine (C-C motif) ligand 19
CKB creatine kinase, brain
CPD carboxypeptidase D
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP3 epithelial membrane protein 3
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM13A family with sequence similarity 13, member A
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GLUL glutamate-ammonia ligase
HEG1 heart development protein with EGF-like domains 1
KIF5C kinesin family member 5C
KRT14 keratin 14, type I
KRT15 keratin 15, type I
MAOA monoamine oxidase A
MARCKS myristoylated alanine-rich protein kinase C substrate
MXRA7 matrix-remodelling associated 7
NXN nucleoredoxin
PEG10 paternally expressed 10
PEX11A peroxisomal biogenesis factor 11 alpha
PLAC8 placenta-specific 8
RBM47 RNA binding motif protein 47
S100A10 S100 calcium binding protein A10
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOAT1 sterol O-acyltransferase 1
STXBP2 syntaxin binding protein 2
TGFB1 transforming growth factor, beta 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ASS1 argininosuccinate synthase 1
CD200 CD200 molecule
CHGB chromogranin B
CLGN calmegin
COL11A1 collagen, type XI, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
ERAP2 endoplasmic reticulum aminopeptidase 2
ESR1 estrogen receptor 1
FAR2 fatty acyl CoA reductase 2
FKBP14 FK506 binding protein 14, 22 kDa
GFOD1 glucose-fructose oxidoreductase domain containing 1
ICA1 islet cell autoantigen 1, 69kDa
IL6ST interleukin 6 signal transducer
LAMA3 laminin, alpha 3
LAMP5 lysosomal-associated membrane protein family, member 5
LOC100505650 uncharacterized LOC100505650
MX1 MX dynamin-like GTPase 1
MYO5C myosin VC
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX2 neuronal pentraxin II
PDGFA platelet-derived growth factor alpha polypeptide
PIP prolactin-induced protein
PSPH phosphoserine phosphatase
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
REG1A regenerating islet-derived 1 alpha
RNASET2 ribonuclease T2
SLC38A1 solute carrier family 38, member 1
SNAP25 synaptosomal-associated protein, 25kDa
SPINT2 serine peptidase inhibitor, Kunitz type, 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SYT1 synaptotagmin I
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDO2 tryptophan 2,3-dioxygenase
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)