BRD-K57282030_JW-7-24-1_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K57282030_JW-7-24-1_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ANKRD36B ankyrin repeat domain 36B
AREG amphiregulin
ASPN asporin
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C8ORF4 chromosome 8 open reading frame 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK19 cyclin-dependent kinase 19
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHGB chromogranin B
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FZD5 frizzled class receptor 5
GNLY granulysin
GSE1 Gse1 coiled-coil protein
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IGHM immunoglobulin heavy constant mu
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JAG1 jagged 1
KIZ kizuna centrosomal protein
KRT18 keratin 18, type I
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LOC100272216 uncharacterized LOC100272216
LUM lumican
LXN latexin
MAGEA3 melanoma antigen family A3
MAN1A1 mannosidase, alpha, class 1A, member 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
NOX4 NADPH oxidase 4
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
OSBPL10 oxysterol binding protein-like 10
PAM peptidylglycine alpha-amidating monooxygenase
PDE9A phosphodiesterase 9A
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTGIS prostaglandin I2 (prostacyclin) synthase
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
RNASE6 ribonuclease, RNase A family, k6
RNF144A ring finger protein 144A
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SH3BGRL SH3 domain binding glutamate-rich protein like
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAR steroidogenic acute regulatory protein
STON1 stonin 1
SULF1 sulfatase 1
SYT1 synaptotagmin I
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
ZMYM2 zinc finger, MYM-type 2
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA6 annexin A6
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALML5 calmodulin-like 5
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CLU clusterin
COL9A3 collagen, type IX, alpha 3
CSE1L CSE1 chromosome segregation 1-like (yeast)
DDIT4 DNA-damage-inducible transcript 4
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EXO1 exonuclease 1
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LIG1 ligase I, DNA, ATP-dependent
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP7 microtubule-associated protein 7
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG non-SMC condensin I complex, subunit G
NET1 neuroepithelial cell transforming 1
NUP107 nucleoporin 107kDa
NUP62 nucleoporin 62kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PITX1 paired-like homeodomain 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRC1 protein regulator of cytokinesis 1
PRPF4 pre-mRNA processing factor 4
PSMC3IP PSMC3 interacting protein
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RNASEH2A ribonuclease H2, subunit A
SHCBP1 SHC SH2-domain binding protein 1
SMC2 structural maintenance of chromosomes 2
SPC25 SPC25, NDC80 kinetochore complex component
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TIMELESS timeless circadian clock
TMEM194A transmembrane protein 194A
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TYMS thymidylate synthetase
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein