BRD-K57282030_JW-7-24-1_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K57282030_JW-7-24-1_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOC1 apolipoprotein C-I
ARMCX1 armadillo repeat containing, X-linked 1
BGN biglycan
CD14 CD14 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CXCR4 chemokine (C-X-C motif) receptor 4
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EDN1 endothelin 1
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FRZB frizzled-related protein
GADD45B growth arrest and DNA-damage-inducible, beta
GSN gelsolin
HES1 hes family bHLH transcription factor 1
HMGB3 high mobility group box 3
HOXD1 homeobox D1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
IER5 immediate early response 5
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
JAM3 junctional adhesion molecule 3
LPCAT1 lysophosphatidylcholine acyltransferase 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
PNMA2 paraneoplastic Ma antigen 2
PTPRE protein tyrosine phosphatase, receptor type, E
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TXNIP thioredoxin interacting protein
UXT ubiquitously-expressed, prefoldin-like chaperone
WDR13 WD repeat domain 13
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADM adrenomedullin
AK4 adenylate kinase 4
ALB albumin
ALDOC aldolase C, fructose-bisphosphate
BAG2 BCL2-associated athanogene 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
CLU clusterin
COL9A3 collagen, type IX, alpha 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM129A family with sequence similarity 129, member A
FAM162A family with sequence similarity 162, member A
FASN fatty acid synthase
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLM glutamate-cysteine ligase, modifier subunit
GLIPR1 GLI pathogenesis-related 1
HAT1 histone acetyltransferase 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HILPDA hypoxia inducible lipid droplet-associated
IFI44L interferon-induced protein 44-like
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
INSIG1 insulin induced gene 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KRT4 keratin 4, type II
LMNA lamin A/C
MAL mal, T-cell differentiation protein
MSMO1 methylsterol monooxygenase 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAX8 paired box 8
PCOLCE2 procollagen C-endopeptidase enhancer 2
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PSAT1 phosphoserine aminotransferase 1
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMYD3 SET and MYND domain containing 3
SPAG4 sperm associated antigen 4
SQLE squalene epoxidase
SRGN serglycin
SRPRB signal recognition particle receptor, B subunit
TARS threonyl-tRNA synthetase
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TXNDC9 thioredoxin domain containing 9
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)