BRD-K57282030_JW-7-24-1_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K57282030_JW-7-24-1_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD36B ankyrin repeat domain 36B
APOC1 apolipoprotein C-I
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMCX6 armadillo repeat containing, X-linked 6
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCL6 B-cell CLL/lymphoma 6
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CD14 CD14 molecule
CLU clusterin
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYBB cytochrome b-245, beta polypeptide
CYTH1 cytohesin 1
DMD dystrophin
DST dystonin
EMP3 epithelial membrane protein 3
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FN1 fibronectin 1
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
HBP1 HMG-box transcription factor 1
HCK HCK proto-oncogene, Src family tyrosine kinase
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HNMT histamine N-methyltransferase
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRF9 interferon regulatory factor 9
KLHDC2 kelch domain containing 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MET MET proto-oncogene, receptor tyrosine kinase
MLPH melanophilin
MTSS1 metastasis suppressor 1
MVP major vault protein
NXT2 nuclear transport factor 2-like export factor 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PTN pleiotrophin
RAB31 RAB31, member RAS oncogene family
RIN2 Ras and Rab interactor 2
RNMT RNA (guanine-7-) methyltransferase
RTN2 reticulon 2
SEPP1 selenoprotein P, plasma, 1
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TLR2 toll-like receptor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ASCL1 achaete-scute family bHLH transcription factor 1
ASPN asporin
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA2 carbonic anhydrase II
CDC20 cell division cycle 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CYCS cytochrome c, somatic
DLC1 DLC1 Rho GTPase activating protein
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FAM162A family with sequence similarity 162, member A
FRZB frizzled-related protein
GNAS GNAS complex locus
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
HIGD1A HIG1 hypoxia inducible domain family, member 1A
IGHD immunoglobulin heavy constant delta
LPL lipoprotein lipase
MAL mal, T-cell differentiation protein
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
MRPL42 mitochondrial ribosomal protein L42
MTCH2 mitochondrial carrier 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
OLFM4 olfactomedin 4
PLN phospholamban
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSPH phosphoserine phosphatase
PTMA prothymosin, alpha
SFRP1 secreted frizzled-related protein 1
SNAP25 synaptosomal-associated protein, 25kDa
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1A small proline-rich protein 1A
TCP1 t-complex 1
TUBG1 tubulin, gamma 1