BRD-K57282030_JW-7-24-1_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K57282030_JW-7-24-1_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARMCX2 armadillo repeat containing, X-linked 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP9A ATPase, class II, type 9A
CAST calpastatin
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCR2 chemokine (C-C motif) receptor 2
CD200 CD200 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CELF2 CUGBP, Elav-like family member 2
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CST1 cystatin SN
CTSK cathepsin K
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP10 dual specificity phosphatase 10
EIF2D eukaryotic translation initiation factor 2D
ETV1 ets variant 1
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
HEXA hexosaminidase A (alpha polypeptide)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTBP2 latent transforming growth factor beta binding protein 2
LXN latexin
MAGEA3 melanoma antigen family A3
MDK midkine (neurite growth-promoting factor 2)
MEST mesoderm specific transcript
MN1 meningioma (disrupted in balanced translocation) 1
MOCOS molybdenum cofactor sulfurase
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NELL2 NEL-like 2 (chicken)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PYCARD PYD and CARD domain containing
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SELENBP1 selenium binding protein 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SSPN sarcospan
SULF1 sulfatase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGIF1 TGFB-induced factor homeobox 1
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TPP1 tripeptidyl peptidase I

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP1 aquaporin 1 (Colton blood group)
ATAD2 ATPase family, AAA domain containing 2
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CIAPIN1 cytokine induced apoptosis inhibitor 1
COL1A1 collagen, type I, alpha 1
COL4A1 collagen, type IV, alpha 1
CPM carboxypeptidase M
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FERMT2 fermitin family member 2
FGFR3 fibroblast growth factor receptor 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA2 GATA binding protein 2
GRAMD3 GRAM domain containing 3
HELLS helicase, lymphoid-specific
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
IL6ST interleukin 6 signal transducer
LGMN legumain
LMNB1 lamin B1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MFAP3L microfibrillar-associated protein 3-like
MGLL monoglyceride lipase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEFL neurofilament, light polypeptide
NRGN neurogranin (protein kinase C substrate, RC3)
PDIA3 protein disulfide isomerase family A, member 3
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
RAD23B RAD23 homolog B (S. cerevisiae)
RAD54B RAD54 homolog B (S. cerevisiae)
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SHCBP1 SHC SH2-domain binding protein 1
SMC4 structural maintenance of chromosomes 4
TUBB2A tubulin, beta 2A class IIa