BRD-K57169635_dacomitinib_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

118 genes differentially expressed following the BRD-K57169635_dacomitinib_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
APOD apolipoprotein D
BAD BCL2-associated agonist of cell death
BST2 bone marrow stromal cell antigen 2
C14ORF132 chromosome 14 open reading frame 132
CAPN1 calpain 1, (mu/I) large subunit
CCDC92 coiled-coil domain containing 92
CD9 CD9 molecule
CLDN10 claudin 10
CP ceruloplasmin (ferroxidase)
CTSB cathepsin B
CTSD cathepsin D
DEFB1 defensin, beta 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FBLN1 fibulin 1
FGB fibrinogen beta chain
FGFR4 fibroblast growth factor receptor 4
FMO3 flavin containing monooxygenase 3
FTH1 ferritin, heavy polypeptide 1
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRRC16A leucine rich repeat containing 16A
LY75 lymphocyte antigen 75
MEIS1 Meis homeobox 1
MMP12 matrix metallopeptidase 12
MOK MOK protein kinase
MUC1 mucin 1, cell surface associated
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PERP PERP, TP53 apoptosis effector
PLA2G16 phospholipase A2, group XVI
PLCB4 phospholipase C, beta 4
PLIN2 perilipin 2
PSAP prosaposin
QPRT quinolinate phosphoribosyltransferase
RAB25 RAB25, member RAS oncogene family
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLPI secretory leukocyte peptidase inhibitor
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
SYT1 synaptotagmin I
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
THAP11 THAP domain containing 11
TKT transketolase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNNC1 troponin C type 1 (slow)
TPP1 tripeptidyl peptidase I
TTC39A tetratricopeptide repeat domain 39A
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
VAT1 vesicle amine transport 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ARL4A ADP-ribosylation factor-like 4A
ARL4C ADP-ribosylation factor-like 4C
CALR calreticulin
CDC42 cell division cycle 42
CHIC2 cysteine-rich hydrophobic domain 2
COL13A1 collagen, type XIII, alpha 1
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DST dystonin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV5 ets variant 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FST follistatin
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IL13RA2 interleukin 13 receptor, alpha 2
INHBA inhibin, beta A
MCM2 minichromosome maintenance complex component 2
MCM6 minichromosome maintenance complex component 6
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYCBP MYC binding protein
NFIB nuclear factor I/B
NT5E 5'-nucleotidase, ecto (CD73)
P3H2 prolyl 3-hydroxylase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PTHLH parathyroid hormone-like hormone
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAD51C RAD51 paralog C
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
TGFB1 transforming growth factor, beta 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing