BRD-K57169635_dacomitinib_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K57169635_dacomitinib_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASPN asporin
BAD BCL2-associated agonist of cell death
BHLHE41 basic helix-loop-helix family, member e41
BHMT2 betaine--homocysteine S-methyltransferase 2
C9ORF3 chromosome 9 open reading frame 3
CA12 carbonic anhydrase XII
CAPN1 calpain 1, (mu/I) large subunit
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN10 claudin 10
COBLL1 cordon-bleu WH2 repeat protein-like 1
CXCL5 chemokine (C-X-C motif) ligand 5
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEFB1 defensin, beta 1
DMTF1 cyclin D binding myb-like transcription factor 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
F13A1 coagulation factor XIII, A1 polypeptide
FNBP1L formin binding protein 1-like
FXYD2 FXYD domain containing ion transport regulator 2
HIST1H2AC histone cluster 1, H2ac
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT19 keratin 19, type I
LOC100505650 uncharacterized LOC100505650
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NNMT nicotinamide N-methyltransferase
NOTCH1 notch 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PDZK1 PDZ domain containing 1
PIR pirin (iron-binding nuclear protein)
PXDN peroxidasin
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TLR4 toll-like receptor 4
TMEM47 transmembrane protein 47
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIM29 tripartite motif containing 29
WFDC2 WAP four-disulfide core domain 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AADAC arylacetamide deacetylase
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
CAV1 caveolin 1, caveolae protein, 22kDa
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
CYR61 cysteine-rich, angiogenic inducer, 61
DFNA5 deafness, autosomal dominant 5
DUSP6 dual specificity phosphatase 6
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ETV1 ets variant 1
ETV5 ets variant 5
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
GNG12 guanine nucleotide binding protein (G protein), gamma 12
HBEGF heparin-binding EGF-like growth factor
HK2 hexokinase 2
IER3 immediate early response 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LGALS1 lectin, galactoside-binding, soluble, 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MCL1 myeloid cell leukemia 1
MT1E metallothionein 1E
NFIB nuclear factor I/B
NPTX1 neuronal pentraxin I
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB20 RAB20, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
STK17A serine/threonine kinase 17a
TGFBI transforming growth factor, beta-induced, 68kDa
TM9SF3 transmembrane 9 superfamily member 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
UGCG UDP-glucose ceramide glucosyltransferase
VDAC1 voltage-dependent anion channel 1
YME1L1 YME1-like 1 ATPase