BRD-K57080016_selumetinib_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

57 genes differentially expressed following the BRD-K57080016_selumetinib_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
CA2 carbonic anhydrase II
CD36 CD36 molecule (thrombospondin receptor)
CENPU centromere protein U
CORO1C coronin, actin binding protein, 1C
DAPK1 death-associated protein kinase 1
DST dystonin
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HBD hemoglobin, delta
HOMER3 homer scaffolding protein 3
KIAA0101 KIAA0101
KYNU kynureninase
MMP1 matrix metallopeptidase 1
NNMT nicotinamide N-methyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NRGN neurogranin (protein kinase C substrate, RC3)
NXN nucleoredoxin
PIR pirin (iron-binding nuclear protein)
PLK2 polo-like kinase 2
PROM1 prominin 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SNAP25 synaptosomal-associated protein, 25kDa
TAGLN2 transgelin 2
TWF1 twinfilin actin binding protein 1

decreased expression

Symbol Name
CANT1 calcium activated nucleotidase 1
CERS6 ceramide synthase 6
COCH cochlin
DHRS2 dehydrogenase/reductase (SDR family) member 2
EFNB2 ephrin-B2
FAS Fas cell surface death receptor
FBN2 fibrillin 2
FST follistatin
FSTL1 follistatin-like 1
IGKV1-5 immunoglobulin kappa variable 1-5
JAM3 junctional adhesion molecule 3
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS4 lectin, galactoside-binding, soluble, 4
PDGFD platelet derived growth factor D
PPAP2B phosphatidic acid phosphatase type 2B
PRKCA protein kinase C, alpha
PTCH1 patched 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SIRT3 sirtuin 3
TBX2 T-box 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
WLS wntless Wnt ligand secretion mediator