BRD-K57080016_selumetinib_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K57080016_selumetinib_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C2 aldo-keto reductase family 1, member C2
BHLHE41 basic helix-loop-helix family, member e41
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H1C histone cluster 1, H1c
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HP haptoglobin
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL1R2 interleukin 1 receptor, type II
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KRT19 keratin 19, type I
MDK midkine (neurite growth-promoting factor 2)
MUC16 mucin 16, cell surface associated
MZB1 marginal zone B and B1 cell-specific protein
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
QPRT quinolinate phosphoribosyltransferase
SCYL3 SCY1-like 3 (S. cerevisiae)
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SYNE2 spectrin repeat containing, nuclear envelope 2
TMEM87A transmembrane protein 87A
TNFRSF17 tumor necrosis factor receptor superfamily, member 17

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
CCND1 cyclin D1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
COL4A5 collagen, type IV, alpha 5
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA2 EPH receptor A2
EREG epiregulin
ETV5 ets variant 5
FOSL1 FOS-like antigen 1
GJA1 gap junction protein, alpha 1, 43kDa
HAL histidine ammonia-lyase
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
IER2 immediate early response 2
IER3 immediate early response 3
JUN jun proto-oncogene
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDE4B phosphodiesterase 4B, cAMP-specific
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
SCD5 stearoyl-CoA desaturase 5
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STX1A syntaxin 1A (brain)
THBD thrombomodulin
TLR4 toll-like receptor 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b