BRD-K57080016_selumetinib_MDAMB231_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

57 genes differentially expressed following the BRD-K57080016_selumetinib_MDAMB231_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP3 aquaporin 3 (Gill blood group)
CA12 carbonic anhydrase XII
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEMIP cell migration inducing protein, hyaluronan binding
CLCA2 chloride channel accessory 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSG3 desmoglein 3
ERBB2 erb-b2 receptor tyrosine kinase 2
GAS1 growth arrest-specific 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IGFBP5 insulin-like growth factor binding protein 5
LTBP1 latent transforming growth factor beta binding protein 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SEPP1 selenoprotein P, plasma, 1
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
TRAM1 translocation associated membrane protein 1
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
CCL5 chemokine (C-C motif) ligand 5
DMXL2 Dmx-like 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPCAM epithelial cell adhesion molecule
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GDF15 growth differentiation factor 15
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KIF5C kinesin family member 5C
KRT19 keratin 19, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCTP1 multiple C2 domains, transmembrane 1
MLPH melanophilin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
RTN1 reticulon 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21