BRD-K57080016_selumetinib_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-K57080016_selumetinib_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AMOTL2 angiomotin like 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX3 armadillo repeat containing, X-linked 3
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
C6ORF62 chromosome 6 open reading frame 62
CLIC3 chloride intracellular channel 3
COL5A1 collagen, type V, alpha 1
CTSA cathepsin A
CYB5A cytochrome b5 type A (microsomal)
DHCR24 24-dehydrocholesterol reductase
DLC1 DLC1 Rho GTPase activating protein
FILIP1L filamin A interacting protein 1-like
FOSL2 FOS-like antigen 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GPC1 glypican 1
GRAMD3 GRAM domain containing 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
ITGAV integrin, alpha V
KIAA0355 KIAA0355
KIAA1033 KIAA1033
LDLR low density lipoprotein receptor
LMCD1 LIM and cysteine-rich domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED2 melanoma antigen family D2
MUC1 mucin 1, cell surface associated
MYL9 myosin, light chain 9, regulatory
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
OPTN optineurin
OXTR oxytocin receptor
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PALLD palladin, cytoskeletal associated protein
PDLIM1 PDZ and LIM domain 1
PDZD2 PDZ domain containing 2
PLS3 plastin 3
PROS1 protein S (alpha)
PXDC1 PX domain containing 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RPL37A ribosomal protein L37a
SERINC3 serine incorporator 3
SQSTM1 sequestosome 1
TAGLN transgelin
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMOD1 tropomodulin 1
TNNC1 troponin C type 1 (slow)
TPM1 tropomyosin 1 (alpha)
UGCG UDP-glucose ceramide glucosyltransferase
UPK3B uroplakin 3B
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
ANO1 anoctamin 1, calcium activated chloride channel
ANPEP alanyl (membrane) aminopeptidase
APOD apolipoprotein D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIK BCL2-interacting killer (apoptosis-inducing)
C16ORF45 chromosome 16 open reading frame 45
CA2 carbonic anhydrase II
CCND1 cyclin D1
CD320 CD320 molecule
CD9 CD9 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CXCR4 chemokine (C-X-C motif) receptor 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFHD2 EF-hand domain family, member D2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA3 EPH receptor A3
EREG epiregulin
F5 coagulation factor V (proaccelerin, labile factor)
FANCI Fanconi anemia, complementation group I
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
FZD1 frizzled class receptor 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAL galanin/GMAP prepropeptide
HES1 hes family bHLH transcription factor 1
HK2 hexokinase 2
HMGB1 high mobility group box 1
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IRX5 iroquois homeobox 5
LTF lactotransferrin
LYZ lysozyme
MAOB monoamine oxidase B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NELL2 NEL-like 2 (chicken)
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PCOLCE2 procollagen C-endopeptidase enhancer 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAGP small cell adhesion glycoprotein
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYT1 synaptotagmin I
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TF transferrin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52 tumor protein D52
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2