BRD-K57080016_selumetinib_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K57080016_selumetinib_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BTG1 B-cell translocation gene 1, anti-proliferative
C11ORF71 chromosome 11 open reading frame 71
CCL19 chemokine (C-C motif) ligand 19
CD99 CD99 molecule
CLU clusterin
CRYAB crystallin, alpha B
CXCL5 chemokine (C-X-C motif) ligand 5
DCPS decapping enzyme, scavenger
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
F8 coagulation factor VIII, procoagulant component
FGF13 fibroblast growth factor 13
FMO2 flavin containing monooxygenase 2 (non-functional)
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
H2AFX H2A histone family, member X
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL6R interleukin 6 receptor
IL7R interleukin 7 receptor
ITM2A integral membrane protein 2A
LCN2 lipocalin 2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEX11A peroxisomal biogenesis factor 11 alpha
PHYH phytanoyl-CoA 2-hydroxylase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RDX radixin
RGS1 regulator of G-protein signaling 1
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A10 S100 calcium binding protein A10
SCYL3 SCY1-like 3 (S. cerevisiae)
SYBU syntabulin (syntaxin-interacting)
TAGLN transgelin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSC22D3 TSC22 domain family, member 3
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
CARD10 caspase recruitment domain family, member 10
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPHA2 EPH receptor A2
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
ISG15 ISG15 ubiquitin-like modifier
ITGB7 integrin, beta 7
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSMO1 methylsterol monooxygenase 1
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEB nebulin
NOP2 NOP2 nucleolar protein
NPAS2 neuronal PAS domain protein 2
NT5E 5'-nucleotidase, ecto (CD73)
OSBPL10 oxysterol binding protein-like 10
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PTX3 pentraxin 3, long
SCG5 secretogranin V
SDC1 syndecan 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
STX1A syntaxin 1A (brain)
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SYNJ2 synaptojanin 2
TFF1 trefoil factor 1
TM4SF1 transmembrane 4 L six family member 1
TRIB2 tribbles pseudokinase 2
TTN titin
UPP1 uridine phosphorylase 1
VCAN versican
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2