BRD-K57080016_selumetinib_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K57080016_selumetinib_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BMP4 bone morphogenetic protein 4
BST2 bone marrow stromal cell antigen 2
C1S complement component 1, s subcomponent
CFH complement factor H
CLGN calmegin
CLU clusterin
COL1A2 collagen, type I, alpha 2
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
CXCL12 chemokine (C-X-C motif) ligand 12
DCN decorin
DHCR24 24-dehydrocholesterol reductase
DMD dystrophin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM129A family with sequence similarity 129, member A
FBN1 fibrillin 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GREM1 gremlin 1, DAN family BMP antagonist
HMGN3 high mobility group nucleosomal binding domain 3
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MEIS2 Meis homeobox 2
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
PIR pirin (iron-binding nuclear protein)
PLTP phospholipid transfer protein
PRDX6 peroxiredoxin 6
PRSS23 protease, serine, 23
PSAP prosaposin
PTGDS prostaglandin D2 synthase 21kDa (brain)
RCAN2 regulator of calcineurin 2
RELN reelin
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RTN1 reticulon 1
S100A4 S100 calcium binding protein A4
SCGB2A1 secretoglobin, family 2A, member 1
SFN stratifin
SLPI secretory leukocyte peptidase inhibitor
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
TAGLN2 transgelin 2
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BHLHE40 basic helix-loop-helix family, member e40
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CREB1 cAMP responsive element binding protein 1
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EGR3 early growth response 3
ENOPH1 enolase-phosphatase 1
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
GNLY granulysin
GOLM1 golgi membrane protein 1
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER2 immediate early response 2
IER3 immediate early response 3
ITGA6 integrin, alpha 6
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LPXN leupaxin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NPEPL1 aminopeptidase-like 1
NT5E 5'-nucleotidase, ecto (CD73)
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STX1A syntaxin 1A (brain)
SYNJ2 synaptojanin 2
TBX2 T-box 2
TFF1 trefoil factor 1
TGFA transforming growth factor, alpha
TRIB2 tribbles pseudokinase 2
VEGFA vascular endothelial growth factor A
ZFP36L2 ZFP36 ring finger protein-like 2