BRD-K57080016_selumetinib_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K57080016_selumetinib_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL6 B-cell CLL/lymphoma 6
BTG2 BTG family, member 2
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES1 carboxylesterase 1
CNN1 calponin 1, basic, smooth muscle
COL4A5 collagen, type IV, alpha 5
DDR1 discoidin domain receptor tyrosine kinase 1
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM46A family with sequence similarity 46, member A
FBXO2 F-box protein 2
FOLR1 folate receptor 1 (adult)
GPC4 glypican 4
HIST1H2AC histone cluster 1, H2ac
IGHM immunoglobulin heavy constant mu
IL32 interleukin 32
KLHL21 kelch-like family member 21
KRT18 keratin 18, type I
LIMS2 LIM and senescent cell antigen-like domains 2
MAOB monoamine oxidase B
MEIS1 Meis homeobox 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NEFH neurofilament, heavy polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NXN nucleoredoxin
PDGFA platelet-derived growth factor alpha polypeptide
PPAP2A phosphatidic acid phosphatase type 2A
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB21 RAB21, member RAS oncogene family
RYBP RING1 and YY1 binding protein
SH3BGRL SH3 domain binding glutamate-rich protein like
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A1 solute carrier family 38, member 1
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
TNS1 tensin 1
TOX3 TOX high mobility group box family member 3
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPH aspartate beta-hydroxylase
AURKB aurora kinase B
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CP ceruloplasmin (ferroxidase)
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DOCK4 dedicator of cytokinesis 4
DPYD dihydropyrimidine dehydrogenase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ETV1 ets variant 1
FANCI Fanconi anemia, complementation group I
FANCL Fanconi anemia, complementation group L
FCGBP Fc fragment of IgG binding protein
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
HMGA2 high mobility group AT-hook 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDC80 NDC80 kinetochore complex component
NT5E 5'-nucleotidase, ecto (CD73)
NUP62 nucleoporin 62kDa
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNP purine nucleoside phosphorylase
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RFC4 replication factor C (activator 1) 4, 37kDa
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SHCBP1 SHC SH2-domain binding protein 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UNG uracil-DNA glycosylase