BRD-K57080016_selumetinib_HME1_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K57080016_selumetinib_HME1_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
BIRC3 baculoviral IAP repeat containing 3
CEP57 centrosomal protein 57kDa
CRELD2 cysteine-rich with EGF-like domains 2
CXCL12 chemokine (C-X-C motif) ligand 12
DEPTOR DEP domain containing MTOR-interacting protein
HMG20B high mobility group 20B
HSPA2 heat shock 70kDa protein 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGKV1-5 immunoglobulin kappa variable 1-5
LYZ lysozyme
MFAP3L microfibrillar-associated protein 3-like
MYBPC1 myosin binding protein C, slow type
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
SCAND1 SCAN domain containing 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNNC1 troponin C type 1 (slow)
TSC22D3 TSC22 domain family, member 3
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
APOA2 apolipoprotein A-II
APOB apolipoprotein B
AREG amphiregulin
ATP11B ATPase, class VI, type 11B
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
C1ORF106 chromosome 1 open reading frame 106
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CES1 carboxylesterase 1
COL4A6 collagen, type IV, alpha 6
COL9A3 collagen, type IX, alpha 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA2 EPH receptor A2
FKBP1B FK506 binding protein 1B, 12.6 kDa
GPRC5A G protein-coupled receptor, class C, group 5, member A
HOPX HOP homeobox
IFI44L interferon-induced protein 44-like
IFITM3 interferon induced transmembrane protein 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IL13RA2 interleukin 13 receptor, alpha 2
JADE2 jade family PHD finger 2
LMO3 LIM domain only 3 (rhombotin-like 2)
MPZL2 myelin protein zero-like 2
MUC1 mucin 1, cell surface associated
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
OSMR oncostatin M receptor
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SH2B3 SH2B adaptor protein 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY4 sprouty homolog 4 (Drosophila)
STK26 serine/threonine protein kinase 26
TF transferrin
TGFB1 transforming growth factor, beta 1
TM4SF1 transmembrane 4 L six family member 1
TUBB6 tubulin, beta 6 class V