BRD-K57080016_selumetinib_BT20_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

50 genes differentially expressed following the BRD-K57080016_selumetinib_BT20_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
BZW2 basic leucine zipper and W2 domains 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FBN1 fibrillin 1
FBXO21 F-box protein 21
FN1 fibronectin 1
GNAS GNAS complex locus
IFT57 intraflagellar transport 57
INHBA inhibin, beta A
MAOA monoamine oxidase A
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
PROM1 prominin 1
PSD3 pleckstrin and Sec7 domain containing 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
SORBS3 sorbin and SH3 domain containing 3
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TESC tescalcin
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP1 TIMP metallopeptidase inhibitor 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
AUTS2 autism susceptibility candidate 2
CD24 CD24 molecule
CRYAB crystallin, alpha B
DUSP4 dual specificity phosphatase 4
EFHD1 EF-hand domain family, member D1
EGR3 early growth response 3
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
GCLC glutamate-cysteine ligase, catalytic subunit
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAL mal, T-cell differentiation protein
MBP myelin basic protein
MEF2C myocyte enhancer factor 2C
NAV2 neuron navigator 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SRSF6 serine/arginine-rich splicing factor 6