BRD-K57080016_selumetinib_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K57080016_selumetinib_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ASPN asporin
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BLNK B-cell linker
BST2 bone marrow stromal cell antigen 2
CCPG1 cell cycle progression 1
CD47 CD47 molecule
CFB complement factor B
CHN1 chimerin 1
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CSRP2 cysteine and glycine-rich protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETNK1 ethanolamine kinase 1
F13A1 coagulation factor XIII, A1 polypeptide
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGG fibrinogen gamma chain
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPM6B glycoprotein M6B
GSN gelsolin
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HLA-F major histocompatibility complex, class I, F
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGL immunoglobulin lambda locus
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
LIMCH1 LIM and calponin homology domains 1
MB myoglobin
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MSRB1 methionine sulfoxide reductase B1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MYBPC1 myosin binding protein C, slow type
NUPR1 nuclear protein, transcriptional regulator, 1
PEX11A peroxisomal biogenesis factor 11 alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G16 phospholipase A2, group XVI
POSTN periostin, osteoblast specific factor
PPL periplakin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PROM1 prominin 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTN pleiotrophin
PYCARD PYD and CARD domain containing
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBM47 RNA binding motif protein 47
REEP1 receptor accessory protein 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SCPEP1 serine carboxypeptidase 1
SCRG1 stimulator of chondrogenesis 1
SELENBP1 selenium binding protein 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAGLN transgelin
TJP3 tight junction protein 3
TMEM47 transmembrane protein 47
TPD52L1 tumor protein D52-like 1
TRIM38 tripartite motif containing 38
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
TUBA1A tubulin, alpha 1a
VCAN versican
VGLL4 vestigial-like family member 4
VTCN1 V-set domain containing T cell activation inhibitor 1
WIF1 WNT inhibitory factor 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
AGR2 anterior gradient 2
AKAP12 A kinase (PRKA) anchor protein 12
AREG amphiregulin
AXL AXL receptor tyrosine kinase
BZW2 basic leucine zipper and W2 domains 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CCND2 cyclin D2
CST7 cystatin F (leukocystatin)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DLX2 distal-less homeobox 2
DNMBP dynamin binding protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
F3 coagulation factor III (thromboplastin, tissue factor)
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FYN FYN proto-oncogene, Src family tyrosine kinase
G0S2 G0/G1 switch 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GPX3 glutathione peroxidase 3
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
ITGB5 integrin, beta 5
KRT18 keratin 18, type I
LIF leukemia inhibitory factor
LPL lipoprotein lipase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MCM10 minichromosome maintenance complex component 10
MMP9 matrix metallopeptidase 9
NAV3 neuron navigator 3
NOP56 NOP56 ribonucleoprotein
NT5E 5'-nucleotidase, ecto (CD73)
PA2G4 proliferation-associated 2G4, 38kDa
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PRNP prion protein
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTRF polymerase I and transcript release factor
QPCT glutaminyl-peptide cyclotransferase
RFTN1 raftlin, lipid raft linker 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
STC1 stanniocalcin 1
STK32B serine/threonine kinase 32B
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRBC1 T cell receptor beta constant 1
TSPAN4 tetraspanin 4
TYMS thymidylate synthetase