BRD-K57080016_selumetinib_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

78 genes differentially expressed following the BRD-K57080016_selumetinib_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
AQP3 aquaporin 3 (Gill blood group)
BASP1 brain abundant, membrane attached signal protein 1
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFB complement factor B
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
FOXJ3 forkhead box J3
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
HES1 hes family bHLH transcription factor 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
INA internexin neuronal intermediate filament protein, alpha
ISG15 ISG15 ubiquitin-like modifier
KCNK3 potassium channel, two pore domain subfamily K, member 3
KRT20 keratin 20, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOX lysyl oxidase
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MSLN mesothelin
MUC16 mucin 16, cell surface associated
NEFH neurofilament, heavy polypeptide
NRCAM neuronal cell adhesion molecule
PENK proenkephalin
POSTN periostin, osteoblast specific factor
PRUNE2 prune homolog 2 (Drosophila)
PSCA prostate stem cell antigen
PXDN peroxidasin
RBMS1 RNA binding motif, single stranded interacting protein 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SNAP25 synaptosomal-associated protein, 25kDa
THY1 Thy-1 cell surface antigen
TMEM100 transmembrane protein 100
VGLL1 vestigial-like family member 1

decreased expression

Symbol Name
AREG amphiregulin
CD44 CD44 molecule (Indian blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
DUSP4 dual specificity phosphatase 4
EIF5A eukaryotic translation initiation factor 5A
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EREG epiregulin
FOSL1 FOS-like antigen 1
IER3 immediate early response 3
ITGA6 integrin, alpha 6
KRT6B keratin 6B, type II
LEF1 lymphoid enhancer-binding factor 1
LPXN leupaxin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP7 matrix metallopeptidase 7
PHLDA1 pleckstrin homology-like domain, family A, member 1
PROM1 prominin 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TUBB2A tubulin, beta 2A class IIa